Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI
Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI
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DOI：
10.1016/j.nano.2014.12.007
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发表时间：
2015-04-01
影响因子：
5.4
通讯作者：
Barberi-Heyob, Muriel
中科院分区：
文献类型：
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作者：
Bechet, Denise;Auger, Florent;Barberi-Heyob, Muriel
脑肿瘤的光动力疗法（PDT）似乎是对传统治疗的补充。许多研究表明血管效应在PDT根除肿瘤中的主要作用。对于通过实时成像引导的脑肿瘤的间质PDT（iPDT），已经设计了由靶向神经纤毛蛋白-1（NRP-1）肽的表面定位的肿瘤脉管系统和封装的光敏剂和磁共振成像（MRI）造影剂组成的多功能纳米颗粒。纳米平台赋予细胞光敏性，并表现出对NRP-1的分子亲和力。静脉注射到大鼠颅内胶质瘤表现出动态对比增强的MRI血管生成内皮细胞内衬的新血管主要位于周围的肿瘤。通过使用由NRP-1蛋白表达完成的肿瘤和邻近肿瘤组织的脑的MRI，我们检查了纳米颗粒的选择性。这项研究代表了使用靶向超小型纳米平台通过实时MRI引导的闭头iPDT概念的首次体内验证。(C)2015 Elsevier Inc. All rights reserved.
Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. (C) 2015 Elsevier Inc. All rights reserved.