Synthesis of 5-methylamino-2′-deoxyuridine derivatives
Synthesis of 5-methylamino-2′-deoxyuridine derivatives
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DOI：
10.1081/ncn-100107194
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发表时间：
2001-01-01
影响因子：
1.3
通讯作者：
Varra, N
中科院分区：
文献类型：
--
作者：
Catalanotti, B;Galeone, A;Varra, N
描述了在不同溶剂中3,5'- o -（四异丙基二苯基-1,3-二基）2'-脱氧-5-甲酰基尿嘧啶与几种脂肪胺和芳香胺的还原胺化反应。在脂肪族胺的情况下，预期的C-5取代的甲氨基嘧啶核苷与嘧啶环打开产生的副产物一起形成。副产物的相对量取决于所用溶剂的极性。
Reductive amination of 3,5'-O-(tetraisopropyldisilyloxane-1,3-diyl)2'-deoxy-5-formyluridine with several aliphatic and aromatic amines, in various solvents, is described. In the case of aliphatic amines, the expected C-5 substituted methylamino pyrimidine nucleosides are formed along with by-products deriving from opening of the pyrimidine ring. Relative amounts of the by-products depend upon the polarity of the solvent employed.