Mineralocorticoid receptor function and cognition in health and disease
Mineralocorticoid receptor function and cognition in health and disease
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盐皮质激素受体在健康和疾病中的功能和认知
DOI：
10.1016/j.psyneuen.2018.09.010
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发表时间：
2019
影响因子：
3.7
通讯作者：
Wingenfeld
中科院分区：
文献类型：
--
作者：
Wingenfeld
类固醇激素皮质醇会因压力而释放，并通过两种不同的受体在大脑中发挥作用：盐皮质激素受体 (MR) 和糖皮质激素受体 (GR)。这篇专门针对 Dirk Hellhammer 的综述重点关注 MR 对健康个体和压力相关疾病（如重度抑郁症 (MDD) 或边缘性人格障碍 (BPD)）认知和情绪功能的作用。来自健康个体的动物数据和研究趋同，表明 MR 在评估新情况和随后的反应选择中发挥着重要作用。决策和同理心是这种反应选择的重要决定因素，两者都受到 MR 功能的影响。此外，MR在年轻和老年健康个体的视觉空间导航和记忆中发挥着至关重要的作用，而MR在言语学习和言语记忆中的确切生理作用需要进一步表征。与健康参与者的研究相反，年龄在MR刺激对抑郁症患者认知的影响中发挥了调节作用。在年轻抑郁症患者中，MR 刺激对言语记忆和执行功能产生有益影响，而在老年抑郁症患者中，MR 刺激会导致言语学习和视觉空间记忆受损。与健康对照组类似，BPD 患者在 MR 刺激后表现出情感同理心增强，但认知同理心没有增强。因此，这使得 MR 成为 BPD 心理治疗的潜在药物增强的有趣目标。鉴于 MR 在健康和疾病的认知和情感功能中发挥着重要作用，进一步的研究应该检查 MR 调节是否可以缓解压力相关疾病患者的认知和情感问题。
The steroid hormone cortisol is released in response to stress and exerts its effects in the brain via two different receptors: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). This review - dedicated to Dirk Hellhammer - focusses on the role of MR on cognitive and emotional function in healthy individuals and in stress-associated disorders such as major depressive disorder (MDD) or borderline personality disorder (BPD).Animal data and studies from healthy individuals converge such that MR play an important role in the appraisal of new situations and the following response selection. Decision-making and empathy are important determinants of this response selection and both are affected by MR function. Furthermore, MR are crucially involved in visuospatial navigation and memory in young and elderly healthy individuals whereas the exact physiological role of MR in verbal learning and verbal memory needs to be further characterized.In contrast to studies in healthy participants, age played a moderating role on the effects of MR stimulation on cognition in depressed patients. In young depressed patients, MR stimulation exerted beneficial effects on verbal memory and executive function, whereas in elderly depressed patients MR stimulation led to impaired verbal learning and visuospatial memory. Similar to healthy controls, BPD patients showed enhanced emotional empathy but not cognitive empathy after MR stimulation. Accordingly, this make MR an interesting target for potential pharmacological augmentation of psychotherapy in BPD.Given the important role MR play in cognitive and emotional function in health and disease, further studies should examine whether MR modulation can alleviate cognitive and emotional problems in patients with stress-associated disorders.
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DOI：
10.1038/npp.2012.254
发表时间：
2013-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1002/eat.22113
发表时间：
2013-04
期刊：
The International journal of eating disorders
影响因子：
--
作者：
H. Steiger;B. Labonté;P. Groleau;G. Turecki;Mimi Israel
通讯作者：
H. Steiger;B. Labonté;P. Groleau;G. Turecki;Mimi Israel
影响因子：
3.7
作者：
Behnken, Andreas;Bellingrath, Silja;Zwanzger, Peter
通讯作者：
Zwanzger, Peter
影响因子：
4.1
作者：
Juruena, Mario F.;Pariante, Carmine M.;Cleare, Anthony J.
通讯作者：
Cleare, Anthony J.
原发性肾上腺皮质功能减退症（艾迪生氏病）患者的认知功能
影响因子：
3.7
作者：
K. Schultebraucks;K. Wingenfeld;J. Heimes;M. Quinkler;C. Otte
通讯作者：
C. Otte