Comparing mutational variabilities.
Comparing mutational variabilities.
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DOI：
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发表时间：
1996-07
期刊：
影响因子：
3.3
通讯作者：
David Houle;B. Morikawa;Michael Lynch
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文献类型：
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作者：
David Houle;B. Morikawa;Michael Lynch
我们已经回顾了VM的可用数据，每一代突变产生的表型性状的遗传变异量。我们使用这些数据，使几个定性测试的突变选择平衡假说的遗传方差（MSB）的维护。为了比较VM值，我们使用三个无量纲量：突变遗传力，VM/VE，突变变异系数，CVM;以及常设遗传方差与VM的比值，VC/VM。由于生活史性状的遗传变异系数大于形态性状的遗传变异系数，我们预测，在MSB下，生活史性状也应该有较大的CVM。这一点得到了证实;生活史性状的中位CVM值比形态性状的中位CVM值高6倍以上。VC/VM近似于无限总体中MSB下突变的持续时间。为了保持MSB，VC/VM必须很小，基本上小于1000，生活史性状的值应该小于形态性状。VC/VM在生活史性状上平均约50代，在形态性状上平均约100代。这些观察结果都与突变选择平衡模型的预测一致。
We have reviewed the available data on VM, the amount of genetic variation in phenotypic traits produced each generation by mutation. We use these data to make several qualitative tests of the mutation-selection balance hypothesis for the maintenance of genetic variance (MSB). To compare VM values, we use three dimensionless quantities: mutational heritability, VM/VE, the mutational coefficient of variation, CVM; and the ratio of the standing genetic variance to VM, VC/VM. Since genetic coefficients of variation for life history traits are larger than those for morphological traits, we predict that under MSB, life history traits should also have larger CVM. This is confirmed; life history traits have a median CVM value more than six times higher than that for morphological traits. VC/VM approximates the persistence time of mutations under MSB in an infinite population. In order for MSB to hold, VC/VM must be small, substantially less than 1000, and life history traits should have smaller values than morphological traits. VC/VM averages about 50 generations for life history traits and 100 generations for morphological traits. These observations are all consistent with the predictions of a mutation-selection balance model.