Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential.
Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential.
复制标题
Toll 样受体对成体间充质干细胞活性的调节：对治疗潜力的影响。
DOI：
10.1155/2010/865601
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发表时间：
2010
影响因子：
4.6
通讯作者：
Lombardo, Eleuterio
中科院分区：
文献类型：
--
作者：
DelaRosa, Olga;Lombardo, Eleuterio
间充质干细胞（MSC）作为慢性炎症和自身免疫性疾病的治疗剂特别令人感兴趣。Toll样受体（TLR）配体已经与由于免疫系统永久暴露于TLR特异性刺激物而导致的许多慢性炎性疾病中的炎症持续存在相关联。因此，用于治疗的MSC可能潜在地暴露于TLR配体，其可以调节MSC在体内的治疗潜力。最近的结果表明，MSC被TLR配体激活，导致分化、迁移、增殖、存活和免疫抑制能力的调节。然而，作者之间的不一致的结果表明，MSC的来源，TLR刺激或培养条件发挥作用。值得注意的是，还没有报道TLR配体的激活调节MSC的"免疫豁免"表型，这与使用同种异体MSC-基疗法特别相关。在这篇综述中，我们讨论了现有的数据，通过TLR信号转导的MSC活动的调制。
Mesenchymal stem cells (MSCs) are of special interest as therapeutic agents in the settings of both chronic inflammatory and autoimmune diseases. Toll-like receptors (TLR) ligands have been linked with the perpetuation of inflammation in a number of chronic inflammatory diseases due to the permanent exposure of the immune system to TLR-specific stimuli. Therefore, MSCs employed in therapy can be potentially exposed to TLR ligands, which may modulate MSC therapeutic potential in vivo. Recent results demonstrate that MSCs are activated by TLR ligands leading to modulation of the differentiation, migration, proliferation, survival, and immunosuppression capacities. However inconsistent results among authors have been reported suggesting that the source of MSCs, TLR stimuli employed or culture conditions play a role. Notably, activation by TLR ligands has not been reported to modulate the “immunoprivileged” phenotype of MSCs which is of special relevance regarding the use of allogeneic MSC-based therapies. In this review, we discuss the available data on the modulation of MSCs activity through TLR signalling.
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