Experimental reproduction of severe bluetongue in sheep
Experimental reproduction of severe bluetongue in sheep
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DOI：
10.1354/vp.45-3-310
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发表时间：
2008-05-01
影响因子：
2.4
通讯作者：
Venter, E. H.
中科院分区：
文献类型：
--
作者：
MacLachlan, N. J.;Crafford, J. E.;Venter, E. H.
接种南非蓝舌病（BT）病毒血清型4毒株的绵羊出现了暴发性蓝舌病（BT）病毒特有的严重临床症状和病变，包括冠状炎、口腔和前胃粘膜内层出血和溃疡、肺动脉壁出血以及骨骼肌（尤其是颈部）局灶性广泛坏死。在感染后长达14天的尸检中，受感染的羊表现出明显的肺水肿、头颈部皮下组织和筋膜平面水肿，以及不同严重程度的胸膜和心包积液。绵羊暴发性 BT 实验繁殖的可靠模型将有助于未来的研究，以更好地表征该疾病的发病机制，特别是考虑到血管通透性增加的机制，而血管通透性增加是 BT 和相关轮病毒性疾病（如非洲马病）的特征。
Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.