Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery
Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery
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DOI：
10.4097/kjae.2013.64.2.122
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发表时间：
2013-02-01
影响因子：
2.9
通讯作者：
Kwon, Young Eun
中科院分区：
文献类型：
--
作者：
Kim, Yu Yil;Moon, Soo Yeong;Kwon, Young Eun
背景：术后恶心呕吐（PONV）是麻醉和手术后常见的并发症。本研究旨在比较帕洛诺司琼和昂丹司琼预防妇科腹腔镜手术后高危患者接受静脉阿片类药物自控镇痛（IV-PCA）的PONV的效果。方法：100例非吸烟女性妇科腹腔镜手术患者随机分为帕洛诺司琼组（n = 50）和昂丹司琼组（n = 50）。帕洛诺司琼组静脉推注帕洛诺司琼0.075 mg。恩丹西酮组静脉推注恩丹西酮8 mg，静脉PCA加用恩丹西酮16 mg。结果：两组术后72 h恶心、呕吐发生率无显著性差异（P > 0. 05），术后2 h、24 h、48 h、72 h恶心、呕吐发生率无显著性差异（P > 0. 05）。但是，帕洛诺司琼组的呕吐发生率低于昂丹司琼组（18% vs. 4%，P = 0.025）。在使用止吐药和副作用之间的groups.Conclusions：帕洛诺司琼和昂丹司琼在预防PONV的效果是相似的高危患者接受妇科腹腔镜手术和接受阿片类药物为基础的IV-PCA。（Korean J Anesthesiol 2013; 64：122-126）
Background: Postoperative nausea and vomiting (PONV) are common complications after anesthesia and surgery. This study was designed to compare the effects of palonosetron and ondansetron in preventing PONV in high-risk patients receiving intravenous opioid-based patient-controlled analgesia (IV-PCA) after gynecological laparoscopic surgery.Methods: One hundred non-smoking female patients scheduled for gynecological laparoscopic surgery were randomly assigned into the palonosetron group (n = 50) or the ondansetron group (n = 50). Palonosetron 0.075 mg was injected as a bolus in the palonosetron group. Ondansetron 8 mg was injected as a bolus and 16 mg was added to the IV-PCA in the ondansetron group. The incidences of nausea, vomiting and side effects was recorded at 2 h, 24 h, 48 h and 72 h, postoperatively.Results: There were no significant differences between the groups in the incidence of PONV during 72 h after operation. However, the incidence of vomiting was lower in the palonosetron group than in the ondansetron group (18% vs. 4%, P = 0.025). No differences were observed in use of antiemetics and the side effects between the groups.Conclusions: The effects of palonosetron and ondansetron in preventing PONV were similar in high-risk patients undergoing gynecological laparoscopic surgery and receiving opioid-based IV-PCA. (Korean J Anesthesiol 2013; 64: 122-126)