Effect of arterial CO 2 tension on cerebral blood flow, mean transit time, and vascular volume.
Effect of arterial CO 2 tension on cerebral blood flow, mean transit time, and vascular volume.
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动脉CO 2 张力对脑血流量、平均通过时间和血管容量的影响。
DOI：
10.1152/jappl.1971.31.5.701
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发表时间：
1971
影响因子：
3.3
通讯作者：
H. Wollman
中科院分区：
文献类型：
--
作者：
A. Smith;G. Neufeld;A. Ominsky;H. Wollman
方法美学处理和手术准备。研究了2只公山羊和5只母山羊（平均体重30.1 kg）。每个人都由帆布吊索支撑在一个直立的位置，头部被固定在一根柱子上。麻醉最初由70%的NgO-30%的02从非再呼吸麻醉系统输送。经气管造口置入带口气管内管，并辅以局部麻醉（利多卡因1 70,60-80 mg）。静脉注射d-结核菌碱使患者麻痹，使用限制容量的Bird Mark 8呼吸机控制呼吸。静脉滴注约400ml /hr 0.9% NaCl，加入20meq /l NaHCO3，以补充体液和血液的流失，防止唾液分泌物中碳酸氢盐的流失导致代谢性酸中毒。用电热垫保持体温恒定。左颈动脉通过一个小切口暴露在颈部高位，并在rostra1方向插入一个19号2.5英寸的塑料导管，以便进行血液采样和压力测量。一根16号2.5英寸的导管，可以快速注射示踪剂，被放置在颈静脉中，其尖端指向心脏。然后将颈部血管上的皮肤闭合。开颅以暴露矢状窦，并插入导管，与颈动脉导管相同，其尖端指向前方。手术准备完成后，将麻醉混合物改为50% NZO-50% O2。N20浓度降低后脉搏和血压没有变化，这表明麻醉水平令人满意。一氧化二氮麻醉在男性中显示对CBF的影响很小（32）。监控。用戈达特红外分析仪连续监测末潮PCO~(PET&)，该分析仪通过气管内的塑料导管采集气体。通过将CO%添加到吸入混合物中，以最小程度地改变肺通气，PETIT*保持在所需水平。用斯坦姆应变计测量动脉和脑静脉压。两种压力的零参考平面设置在第一胸椎的水平。应变计和COP分析仪的输出记录在吉尔森测谎仪上。用热敏电阻探头监测直肠温度。用合适的电极和校正因子测定动脉和脑静脉Pcoa、Paz和pH（26）。
METHODSAnesthetic management and surgical preparation. Two male and five female adult goats (mean weight 30.1 kg) were studied. Each was supported in an upright position by a canvas sling and the head was held in a stanchion. Anesthesia consisted initially of 70% NgO-30% 02 delivered from a nonrebreathing anesthesia system. A cuffed endotracheal tube was inserted through a tracheostomy, which was performed with supplemental local anesthesia (lido-Caine 1 70, 60-80 mg). Paralysis was obtained with intravenous d-tubocurarine and respiration was controlled with a volume-limited Bird Mark 8 ventilator. Approximately 400 ml/hr of 0.9% NaCl, with 20 mEq/liter NaHCO3 added, were infused intravenously to replace fluid and blood losses and to prevent metabolic acidosis from loss of bicarbonate in the salivary secretions. Body temperature was maintained constant with an electric heating pad. The left carotid artery was exposed high in the neck through a small incision and a 19-gauge 2.5-inch plastic catheter was inserted in a rostra1 direction to permit blood sampling and pressure measurements. A 16-gauge 2.5-inch catheter, which permitted rapid injection of tracer, was placed in the jugular vein with its tip pointing toward the heart. The skin over the neck vessels was then closed. A craniotomy was performed to expose the sagittal sinus and a catheter, identical to that used in the carotid artery, was inserted with its tip pointing anteriorly. The anesthetic mixture was changed to 50% NZO-50% O2 after the surgical preparations had been completed. A satisfactory anesthetic level was indicated by the fact that no changes in pulse or blood pressure occurred after the N20 concentration had been decreased. Nitrous oxide anesthesia has been shown in man to have minimal effects on CBF (32). Monitoring. End-tidal PCO~(PET& was continuously monitored with a Godart infrared analyzer, which sampled gas through a plastic catheter in the trachea. The PETIT* was kept at the desired level by adding CO% to the inspired mixture with minimal alteration of pulmonary ventilation. Arterial and cerebral venous pressures were transduced by Statham strain gauges. The zero reference plane for both pressures was set at the level of the first thoracic vertebra. The outputs of the strain gauges and the COP analyzer were recorded on a Gilson polygraph. Rectal temperature was monitored with a thermistor probe. Arterial and cerebral venous Pcoa, Paz, and pH were determined with appropriate electrodes and correction factors (26).