The BRCA1 C-terminal domain: structure and function
The BRCA1 C-terminal domain: structure and function
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DOI：
10.1016/s0921-8777(00)00034-3
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发表时间：
2000-08-30
期刊：
影响因子：
--
通讯作者：
Freemont, PS
中科院分区：
文献类型：
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作者：
Huyton, T;Bates, PA;Freemont, PS
BRCA1C端区含有一个重复的球状结构域，称为BRCT，存在于许多DNA损伤修复和细胞周期检查点蛋白中。这个结构域超家族的独特多样性使BRCT模块能够相互作用，形成同源/异源BRCT多聚体、BRCT-非BRCT相互作用以及与DNA链断裂的相互作用。BRCT超家族的序列和功能多样性表明，BRCT结构域是进化上方便的相互作用模块。(C)2000年，爱思唯尔科学公司出版。
The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming home/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules. (C) 2000 Published by Elsevier Science B.V.