Default Network Modulation and Large-Scale Network Interactivity in Healthy Young and Old Adults
Default Network Modulation and Large-Scale Network Interactivity in Healthy Young and Old Adults
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DOI：
10.1093/cercor/bhr339
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发表时间：
2012-11-01
期刊：
影响因子：
3.7
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Spreng, R. Nathan;Schacter, Daniel L.
我们调查了年轻人和老年人在默认、注意和控制网络活动及其相互作用方面与年龄相关的变化。自传体和视觉空间规划过程中的大脑活动使用多变量分析进行评估，并将内在连接网络作为感兴趣区域。在这两组人中，自传体计划使用默认网络，而视觉空间计划使用注意网络，这与内化和外化认知领域之间的竞争一致。控制网络被用于这两项计划任务。在年轻被试中，控制网络在自传式规划中与默认网络耦合，在视觉空间规划中与注意网络耦合。在老年人中，在两种计划任务中都观察到了默认-控制网络耦合，而老年人在视觉空间计划过程中未能去激活默认网络。这一失败本身并不意味着默认网络功能障碍，自传式规划过程中的默认网络参与就是明证。相反，未能调制老年人的默认网络表明，灵活的网络交互程度较低，网络调制对不断变化的任务需求的动态范围减小。
We investigated age-related changes in default, attention, and control network activity and their interactions in young and old adults. Brain activity during autobiographical and visuospatial planning was assessed using multivariate analysis and with intrinsic connectivity networks as regions of interest. In both groups, autobiographical planning engaged the default network while visuospatial planning engaged the attention network, consistent with a competition between the domains of internalized and externalized cognition. The control network was engaged for both planning tasks. In young subjects, the control network coupled with the default network during autobiographical planning and with the attention network during visuospatial planning. In old subjects, default-to-control network coupling was observed during both planning tasks, and old adults failed to deactivate the default network during visuospatial planning. This failure is not indicative of default network dysfunction per se, evidenced by default network engagement during autobiographical planning. Rather, a failure to modulate the default network in old adults is indicative of a lower degree of flexible network interactivity and reduced dynamic range of network modulation to changing task demands.