Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation.

Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation.
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DOI：
10.2131/jts.38.151
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发表时间：
2013-02
期刊：
The Journal of toxicological sciences
影响因子：
--
通讯作者：
Akiko Honda;C. Watanabe;Minoru Yoshida;H. Nagase;M. Satoh
Akiko Honda;C. Watanabe;Minoru Yoshida;H. Nagase;M. Satoh
中科院分区：
其他
文献类型：
--
作者：
Akiko Honda;C. Watanabe;Minoru Yoshida;H. Nagase;M. Satoh

文献摘要

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含有 30,000 个基因的 DNA 微阵列用于监测镉 (Cd) 暴露后新生儿大脑的转录反应。 C57BL/6J 怀孕小鼠在妊娠和哺乳期间通过饮用水接触镉 (10 ppm)。在暴露于镉的新生儿大脑和对照之间的比较中，包括转铁蛋白受体（Tfrc）在内的三个基因上调，而一个基因下调。
DNA microarray containing 30,000 genes was used to monitor the transcriptional response of the neonatal brain after cadmium (Cd) exposure. C57BL/6J pregnant mice were exposed to Cd (10 ppm) during gestation and lactation via drinking water. In a comparison between the Cd-exposed neonatal brain and control, three genes including transferrin receptor (Tfrc) were up-regulated and one gene was down-regulated.