Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa
Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa
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DOI：
10.1002/eat.22334
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发表时间：
2015-09-01
影响因子：
5.5
通讯作者：
Suvisaari, Jaana
中科院分区：
文献类型：
--
作者：
Raevuori, Anu;Suokas, Jaana;Suvisaari, Jaana
目的：研究暴食症（BED）、神经性贪食症（BN）和神经性厌食症患者中2型糖尿病（T2D）的患病率和发病率。方法将在赫尔辛基大学中心医院饮食失调科治疗的患者（N= 2342）与匹配的普通人群对照（N= 9368）进行为期16年的比较，分为三个阶段：进入饮食失调治疗前、进入饮食失调治疗后至研究期结束后，以及治疗前、治疗中和治疗后的任何时间。研究人群与医疗报销登记册中17年的口服创伤后应激障碍药物数据相关联。数据分析采用条件回归模型和泊松回归模型。结果在开始进食障碍治疗前，患者发生T2D的风险明显高于对照组（OR 6.6, 95% CI 4.0-10.7）。在研究期结束时，患者的T2D终生患病率为5.2%，对照组为1.7% (OR 3.4, 95% CI 2.6-4.4)，男性患者的T2D终生患病率明显高于女性。在接受BED治疗的患者中，三分之一的患者在研究期结束时患有T2D (OR 12.9, 95% CI 7.4-22.5)，而患有BN的患者中，这一比例为4.4% （OR 2.4, 95% CI 1.7-3.5）。我们的研究结果为T2D与临床显著的暴饮暴食之间的联系提供了强有力的支持。葡萄糖代谢紊乱可能有助于BED和BN的发生和维持。(c) 2014 Wiley期刊，Inc.（国际饮食杂志2015；48:55 -562）
ObjectiveWe aimed to examine the prevalence and incidence of type 2 diabetes (T2D) in a large patient cohort treated for binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa.MethodPatients (N=2,342) treated at the Eating Disorder Unit of Helsinki University Central Hospital over the period up to 16 years were compared with matched general population controls (N=9,368) in three stages: before entering to the treatment for an eating disorder, after the entrance until the end of the study period, and combined any time before, during, and after the treatment. The study population was linked with the oral TSD medication data of 17 years from The Medical Reimbursement Register. Data were analyzed using conditional and Poisson regression models.ResultsBefore entering to the treatment for eating disorders, the risk of T2D was substantially increased in patients compared with controls (OR 6.6, 95% CI 4.0-10.7). At the end of the study period, the lifetime prevalence of T2D was 5.2% among patients, 1.7% among controls (OR 3.4, 95% CI 2.6-4.4), and in male patients, it was significantly higher compared with females. Of those treated for BED, every third had T2D by the end of the study period (OR 12.9, 95% CI 7.4-22.5), whereas the same was true for 4.4% of those with BN (OR 2.4, 95% CI 1.7-3.5).DiscussionOur findings provide strong support for the association between T2D and clinically significant binge eating. Disturbed glucose metabolism may contribute to the onset and maintenance of BED and BN. (c) 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:555-562)