Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology.
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology.
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DOI：
10.3389/fmolb.2021.671037
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发表时间：
2021
影响因子：
5
通讯作者：
Polacek N
中科院分区：
文献类型：
--
作者：
Fasnacht M;Polacek N
自从“大氧化事件”以来，地球的细胞生命形式不得不科普活性氧（ROS）影响生物分子完整性和阻碍细胞代谢回路的危险。因此，生物圈中活性氧水平的增加代表着压力水平的增加，从而塑造了物种的进化。无论ROS是内源性还是外源性产生的，不同的系统进化来清除ROS并修复它们造成的损伤。如果ROS超过了细胞消除威胁的能力，我们就说氧化应激。氧化应激对细胞的损伤是多种多样的。本文综述了氧化应激对细菌分子生物学中心法则不同步骤的损害，特别关注参与转录和翻译的RNA机器。
Ever since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels and thus shaped the evolution of species. Whether the ROS were produced endogenously or exogenously, different systems evolved to remove the ROS and repair the damage they inflicted. If ROS outweigh the cell’s capacity to remove the threat, we speak of oxidative stress. The injuries through oxidative stress in cells are diverse. This article reviews the damage oxidative stress imposes on the different steps of the central dogma of molecular biology in bacteria, focusing in particular on the RNA machines involved in transcription and translation.