A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions
A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions
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DOI：
10.1111/j.1360-0443.2006.01630.x
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发表时间：
2007-01-01
期刊：
影响因子：
6
通讯作者：
Heath, Andrew C.
中科院分区：
文献类型：
--
作者：
Agrawal, Arpana;Lynskey, Michael T.;Heath, Andrew C.
我们研究了不同的非法药物滥用/依赖的共同发生，并测试这些类和主要精神disorders.Latent类分析之间的关联被用来描述多物质滥用/依赖（AB/D）在43093人谁参加了全国流行病学调查酒精和相关条件。进行多项逻辑回归以检查终生非法药物AB/D类别与性别、年龄和种族之间的关联，以及终生诊断和统计手册第四版（DSM-IV）酒精滥用/依赖、尼古丁依赖、重度抑郁症、广泛性焦虑症、惊恐障碍、社交恐怖症和反社会人格障碍之间的关联。无AB/D（1类：92.5%）、仅大麻AB/D（2类：5.8%）、兴奋剂+致幻剂AB/D（3类：0.6%）、处方药AB/D（4类：0.6%）和多种物质AB/D（5类：0.5%）。重度抑郁症和尼古丁依赖与5级最密切相关。与参考类别（第1类）相比，焦虑症与处方药AB/D类别密切相关，而酒精AB/D和ASPD与第2类、第3类、第4类和第5类相关。在美国人群中，多种物质AB/D模式存在显著异质性，有证据表明，一个亚组具有较高的镇静剂、安定剂和阿片类AB/D比率以及焦虑症病史，一个是兴奋剂/致幻剂组，一个是所有精神疾病发病率升高的高危组，一个是仅使用大麻的轻度AB/D组。在其他样本中复制这些类别具有重要意义，例如表征可能在病因学上多样化的风险组。
We examine the co-occurrence of abuse/dependence across different illicit drugs and test associations between these classes and major psychiatric disorders.Latent class analyses were used to characterize polysubstance abuse/dependence (AB/D) in 43 093 individuals who participated in the National Epidemiological Survey on Alcohol and Related Conditions. Multinomial logistic regression was performed to examine the association between the classes of life-time illicit drug AB/D and gender, age and race, as well as life-time Diagnostic and Statistical Manual version IV (DSM-IV) alcohol abuse/dependence, nicotine dependence, major depressive disorder, generalized anxiety disorder, panic disorder, social phobia and antisocial personality disorder.Five latent classes were identified: no AB/D (class 1: 92.5%), cannabis AB/D only (class 2: 5.8%), stimulants + hallucinogen AB/D (class 3: 0.6%), prescription drug AB/D (class 4: 0.6%) and polysubstance AB/D (class 5: 0.5%). Major depressive disorder and nicotine dependence were associated most strongly with class 5. Anxiety disorders were associated strongly with the prescription drug AB/D class while alcohol AB/D and ASPD were associated with classes 2, 3, 4 and 5 when compared to the reference class (class 1).Significant heterogeneity exists in this US population for polysubstance AB/D patterns with evidence for a subgroup with high rates of sedative, tranquilizer and opiate AB/D and a history of anxiety disorders, a stimulant/hallucinogens group, a high-risk group with elevated rates of all psychiatric disorders and a milder cannabis AB/D only group. Replication of such classes across other samples has significant implications, such as characterizing risk groups that may be etiologically diverse.