Sweet's syndrome and malignancy in the UK
Sweet's syndrome and malignancy in the UK
复制标题
DOI：
10.1111/j.1365-2133.1997.tb03796.x
复制
发表时间：
1997-10-01
影响因子：
10.3
通讯作者：
GrahamBrown, RAC
中科院分区：
文献类型：
--
作者：
Bourke, JF;Keohane, S;GrahamBrown, RAC
据报道，急性发热性嗜中性皮肤病（Sweet综合征）是潜在恶性肿瘤的标志物，这方面的许多证据是基于病例报告、小系列病例和文献综述。为了阐明Sweet综合征与恶性肿瘤的关系并确定其共同的临床特征，我们回顾了英国6个皮肤科的病例记录。87例组织学证实的Sweet综合征进行了审查。14例患者（16%）发生了相关恶性肿瘤，主要是血液系统恶性肿瘤，2例患者（2%）有既往恶性肿瘤史，4例患者（5%）有癌前病变（单克隆丙种球蛋白病，2例;骨髓增生异常，2例），在Sweet综合征出现后一年内发生了恶性肿瘤。合并恶性肿瘤的患者更可能贫血（P < 0.01），平均血小板计数较低（207 x 10（9）/L vs. 332 x 10（9）/ L; P < 0.003），平均年龄较大（59岁对49岁; P = 0.002），与以前的报告相反，女性发生恶性肿瘤的百分比高于男性。
Acute febrile neutrophilic dermatosis (Sweet's syndrome) is reported to be a marker for underlying malignancy, Much of the evidence for this is based on case reports, small series of cases and reviews of the literature. In order to clarify the association with malignancy and determine the common clinical features of Sweet's syndrome, we reviewed the case notes of patients presenting to six dermatology units in the U.K. Eighty-seven cases of histologically proven Sweet's syndrome were reviewed. Fourteen patients (16%) developed associated malignancy, predominantly haematological, two patients (2%) had a history of previous malignancy and four patients (5%) had premalignant conditions (monoclonal gammopathy, two; myelodysplasia, two), Malignancy developed up to a year after presentation with Sweet's syndrome. Patients with associated malignancy were more likely to be anaemic (P < 0.01) at presentation, had a lower mean platelet count (207 x 10(9)/L, vs. 332 x 10(9)/ L; P < 0.003) and were, on average, older (59 years vs. 49 years; P = 0.002), Contrary to previous reports, a greater percentage of females developed malignancy than males.