SELECTIVE TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS FROM MOTHERS TO INFANTS
SELECTIVE TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS FROM MOTHERS TO INFANTS
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DOI：
10.1126/science.1546316
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发表时间：
1992-02-28
期刊：
影响因子：
56.9
通讯作者：
MUNOZ, JL
中科院分区：
文献类型：
--
作者：
WOLINSKY, SM;WIKE, CM;MUNOZ, JL
从三对母婴中分析了包膜基因V3和V4-V5区的多个人类免疫缺陷病毒1型序列。婴儿的病毒序列没有母亲的那么多样化。在两对中，一种在母亲中不常见的前病毒形式在婴儿中占主导地位。在每个母亲的序列集中存在的V3区域内的保守的N-连接糖基化位点在所有婴儿的序列集中不存在。这些发现表明，母体病毒的一小部分会传播给婴儿。
Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.