Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons
Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons
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DOI：
10.1037/0735-7044.117.4.760
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发表时间：
2003-08-01
影响因子：
1.9
通讯作者：
Nicolelis, MAL
中科院分区：
文献类型：
--
作者：
Matell, MS;Meck, WH;Nicolelis, MAL
本研究探讨了大鼠纹状体和皮层神经元在时间概括任务中的放电模式。纹状体和皮质合奏记录在大鼠训练杠杆按在2个可能的标准持续时间（10秒或40秒，从音调开始）。22%的纹状体细胞和15%的皮质细胞在其放电频率上具有时间特异性调制，与40 s相比，10 s左右的放电频率显著不同。在80%的试验中，对神经元集合的放电率的试验一致性的事后分析预测了尖峰序列是否来自大约10 s与大约40 s的时间窗口。结果表明，纹状体和皮层神经元编码特定的持续时间在其放电率，从而作为一个神经回路的组成部分，用于代表持续时间。
This study investigated the firing patterns of striatal and cortical neurons in rats in a temporal generalization task. Striatal and cortical ensembles were recorded in rats trained to lever press at 2 possible criterion durations (10 s or 40 s from tone onset). Twenty-two percent of striatal and 15% of cortical cells had temporally specific modulations in their firing rate, firing at a significantly different rate around 10 s compared with 40 s. On 80% of trials, a post hoc analysis of the trial-by-trial consistency of the firing rates of an ensemble of neurons predicted whether a spike train came from a time window around 10 s versus around 40 s. Results suggest that striatal and cortical neurons encode specific durations in their firing rate and thereby serve as components of a neural circuit used to represent duration.