Effects of dietary fish oil on Rb+ efflux from aorta of stroke prone spontaneously hypertensive rats.
Effects of dietary fish oil on Rb+ efflux from aorta of stroke prone spontaneously hypertensive rats.
复制标题
膳食鱼油对易发生中风的自发性高血压大鼠主动脉 Rb 流出的影响。
DOI：
10.1093/ajh/5.7.473
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发表时间：
1992
影响因子：
3.2
通讯作者：
Labak,S
中科院分区：
文献类型：
--
作者：
Smith,JM;Paulson,DJ;Labak,S
观察了鱼油对易卒中型自发性高血压大鼠（SHRSP）心房肌钾外流和基础张力的影响。将4周龄雄性Wistar-Kyoto大鼠（WKY）和SHRSP分为两组：一组接受5%玉米油饮食，另一组接受5%鲱鱼油饮食。15周后，与SHRSP-玉米（227 ± 4）相比，SHRSP-鱼（202 ± 5）的平均收缩压（mmHg）降低。WKY-fish和WKY-corn的收缩压分别为146 ± 3和151 ± 4。用同位素~（86）Rb评价钾外流。与WKY玉米相比，SHRSP玉米的主动脉基础86 Rb流出量增加。地尔硫卓或硝普钠可降低SHRSP的86 Rb外排和基础张力。Basal 86 Rb流出，张力，和这种地尔硫或硝普钠诱导的抑制的幅度在SHRSP-鱼减少。在最大地尔硫卓或硝普钠浓度下，两个SHRSP饮食组的86 Rb流出量相似，但仍大于对照组主动脉。地尔硫卓或硝普钠对SHRSP 86 Rb外排和张力的IC 50值不受饮食影响。与WKY-玉米相比，WKY-鱼中注意到基础Rb流出和张力的定性相似变化。这些实验表明，膳食鱼油补充剂降低钙敏感的86 Rb流出和血管平滑肌的基础张力，并建议这些变化可能有助于饮食鱼油在SHRSP伴随的抗高血压作用。美国高血压杂志1992;5：473-479
The effect of fish oil on potassium efflux and basal tension in aortas from stroke prone spontaneously hypertensive rats (SHRSP) was evaluated. Fourweek-old male Wistar-Kyoto rats (WKY) and SHRSP were divided into two groups: one received a 5% corn oil diet; the other a 5% menhaden oil diet. After 15 weeks, mean systolic blood pressure (mm Hg) was reduced in SHRSP-fish (202 ± 5) compared to SHRSP-corn (227 ± 4). Systolic pressure of WKY-fish (146 ± 3) was not different from WKYcorn (151 ± 4). Potassium efflux was evaluated with the isotope86Rb. Basal86Rb efflux from aorta of SHRSP-corn was elevated compared to WKY-corn. Diltiazem or sodium nitroprusside decreased86Rb efflux and basal tension in SHRSP. Basal86Rb efflux, tension, and the magnitude of this diltiazemor nitroprusside-induced inhibition were decreased in SHRSP-fish. At maximal diltiazem or nitroprusside concentration,86Rb efflux from both SHRSP dietary groups was similar but still greater than control aorta. The IC50values for diltiazem or nitroprusside effects on86Rb efflux and tension were not altered by diet in SHRSP. Qualitatively similar changes in basal "Rb efflux and tension were noted in WKY-fish compared to WKY-corn. These experiments demonstrate that dietary fish oil supplementation decreased calcium-sensitive86Rb efflux and basal tension in vascular smooth muscle and suggest that these changes may contribute to the concomitant antihypertensive effect of dietary fish oil in SHRSP. Am J Hypertens 1992;5:473–479