The two binding‐site models of human IgG binding Fcγ receptors
The two binding‐site models of human IgG binding Fcγ receptors
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人 IgG 结合 Fcγ 受体的两种结合位点模型
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
G. Sármay
中科院分区：
文献类型：
--
作者：
J. Gergely;G. Sármay
Fc receptors (FcR) are immunoglobulin‐binding molecules that enable antibodies to perform several biological functions by forming a link between specific antigen recognition and effector cells. FcRs are involved in regulating antibody production as well. Most FcRs belong to the immunoglobulin superfamily, and show structural homology with each other and with their ligands. Recent data on the structure of IgG binding FcRs obtained from monoclonal antibodies and gene cloning studies, as well as on ligand binding capacity and fine specificity of the receptor binding site (or sites), are reviewed. The binding capacity and fine specificity of receptor binding sites, as well as the structure and conformation of the immunoglobulin ligands, play important roles in triggering FcR‐mediated signals. In induction of signals, the interaction of the FcR with the CH2 domain of the IgGFc is decisive. The high‐affinity FcγRI possess one active binding site specific for contact residues that is located at the N‐proximal end of the CH2 domain and is able to mediate both binding and signal transfer. The low‐affinity FCγRIII has two active binding sites: the CH3 domain‐specific site, which mediates only binding; and the CH2 domain‐specific site, which is responsible for binding and signaling. Similarly, the low‐affinity FCγRII on resting B cells has one site for CH2 and another for CH3 binding. The expression, release, and fine specificity of FCγRII on B cells correlates with the cell cycle.—Gergely, J.; Sarmay, G. The two binding‐site models of human IgG binding Fcγ receptors. FASEB J. 4: 3275–3283; 1990.
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人类 IgG Fc 受体的表征。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Vaughn,M;Taylor,M;Mohanakumar,T
通讯作者：
Mohanakumar,T
人巨噬细胞系 U937 上 IgG Fc 受体的表征。
DOI：
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发表时间：
1980
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Anderson,CL;Abraham,GN
通讯作者：
Abraham,GN
通过 B73.1（一种阻断 Fc 受体功能的单克隆抗体）分析人类自然杀伤细胞。
DOI：
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发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Perussia,B;Acuto,O;Terhorst,C;Faust,J;Lazarus,R;Fanning,V;Trinchieri,G
通讯作者：
Trinchieri,G
人类单核细胞和 U937 细胞具有两种不同的 IgG Fc 受体。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Looney,RJ;Abraham,GN;Anderson,CL
通讯作者：
Anderson,CL
影响因子：
15.9
作者：
ROSENFELD, SI;LOONEY, RJ;ANDERSON, CL
通讯作者：
ANDERSON, CL