The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging.
The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging.
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骨细胞来源的细胞外囊泡对阿尔茨海默病的保护作用随着年龄的增长而减弱
DOI：
10.1002/advs.202105316
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发表时间：
2022-06
期刊：
影响因子：
15.1
通讯作者：
Shen, Lu
中科院分区：
文献类型：
--
作者：
Jiang, Ya-Ling;Wang, Zhen-Xing;Liu, Xi-Xi;Wan, Mei-Dan;Liu, Yi-Wei;Jiao, Bin;Liao, Xin-Xin;Luo, Zhong-Wei;Wang, Yi-Yi;Hong, Chun-Gu;Tan, Yi-Juan;Weng, Ling;Zhou, Ya-Fang;Rao, Shan-Shan;Cao, Jia;Liu, Zheng-Zhao;Wan, Teng-Fei;Zhu, Yuan;Xie, Hui;Shen, Lu
Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is found that young osteocyte, the most abundant cells in bone, secretes extracellular vesicles (OCYYoung‐EVs) to ameliorate cognitive impairment and the pathogenesis of AD in APP/PS1 mice and model cells. These benefits of OCYYoung‐EVs are diminished in aged osteocyte‐derived EVs (OCYAged‐EVs). Based on the self‐constructed OCY‐EVs tracer transgenic mouse models and the in vivo fluorescent imaging system, OCY‐EVs have been observed to be transported to the brain under physiological and pathological conditions. In the hippocampal administration of Aβ40 induced young AD model mice, the intramedullary injection of Rab27a‐shRNA adenovirus inhibits OCYYoung‐EVs secretion from bone and aggravates cognitive impairment. Proteomic quantitative analysis reveals that OCYYoung‐EVs, compared to OCYAged‐EVs, enrich multiple protective factors of AD pathway. The study uncovers the role of OCY‐EV as a regulator of brain health, suggesting a novel mechanism in bone‐brain communication. It is found that the osteocyte‐derived extracellular vesicles (OCY‐EVs) isolated from young osteocytes can ameliorate cognitive impairment and pathogenies of AD, but not OCY‐EVs isolated from aged osteocytes. OCY‐EV can transfer to the brain under physiological and pathological conditions. The study uncovers the role of OCY‐EVs as a regulator of brain, suggesting a novel mechanism in bone‐brain communication.
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DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
影响因子：
12.7
作者：
Guo HH;Xiong L;Pan JX;Lee D;Liu K;Ren X;Wang B;Yang X;Cui S;Mei L;Xiong WC
通讯作者：
Xiong WC
影响因子：
2
作者：
Howlett, D. R.;Bowler, K.;Richardson, J. C.
通讯作者：
Richardson, J. C.
影响因子：
25
作者：
Esteve, Pilar;Rueda-Carrasco, Javier;Bovolenta, Paola
通讯作者：
Bovolenta, Paola
影响因子：
82.9
作者：
HAASS, C;LEMERE, CA;SELKOE, DJ
通讯作者：
SELKOE, DJ