Ochratoxin A: Comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans)
Ochratoxin A: Comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans)
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DOI：
10.1080/02652030500309327
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
O'Brien, E
中科院分区：
文献类型：
--
作者：
Dietrich, DR;Heussner, AH;O'Brien, E
与赭曲霉毒素介导的毒性相关的种属和性别差异的因果因素仍不清楚。动力学参数的变化可能在解释这些差异方面发挥重要作用，但是，文献中报告的各种物种的毒代动力学的差异和不准确性使得无法进行比较，因此无法外推到人类情况。目前提出的一室和二室开放模型可能不足以准确地代表体内的实际情况。很可能必须假设至少有三个（如果不是四个）隔室才能解释所报告的影响。将这些模型应用于现有原始数据很可能提供更准确的毒代动力学数据基础集，并有助于更准确的人类风险评估。对报告的不一致性及其对OTA和风险评估的拟议行动机制的影响的可能解释进行了讨论。
The causal factors for the species- and sex-differences associated with ochratoxin-mediated toxicity remain unclear. Variations in kinetic parameters may play a major role in explaining these differences, however, discrepancies and inaccuracies in the toxicokinetics reported in the literature for various species, make comparison and hence the extrapolation to the human situation impossible. The one- and two-compartment open models currently proposed may be insufficient to enable an accurate representation of the actual situation in vivo. It is likely that at least three if not four compartments must be assumed to account for the reported effects. The application of such models to existing raw data would most likely provide for a more accurate base set of toxicokinetic data and contribute to a more accurate human risk assessment. Possible explanations for the reported inconsistencies and their impact on the proposed mechanism(s) of action of OTA and risk assessment are discussed.