Ionic Fluoropolyphosphazenes as Potential Adhesive Agents for Dental Restoration Applications
Ionic Fluoropolyphosphazenes as Potential Adhesive Agents for Dental Restoration Applications
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离子型氟聚磷腈作为牙齿修复应用的潜在粘合剂
DOI：
10.1007/s40883-020-00192-w
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发表时间：
2021
影响因子：
2.6
通讯作者：
Andrianov, Alexander K.
中科院分区：
文献类型：
--
作者：
Weir, Michael D.;Kaner, Papatya;Marin, Alexander;Andrianov, Alexander K.
摘要光活化聚合物基牙科复合材料因其美观、使用方便等优点，已成为临床上修复龋坏牙的首选方法。然而，这些树脂基复合材料牙齿矫正器的寿命可能受到复合材料和牙齿表面之间的粘结界面的敏感性的影响。本研究的目的是用新型氟化聚磷腈（PPZ）修饰牙齿表面，从而提高界面的稳定性。PPZ与胶原蛋白（CLG）和羟基磷灰石（HA），牙齿的两个主要组成部分的结合等温线，建立并表明显着和稳定的吸附到这些材料的表面。PPZ还显示出在模型系统中保护CLG免受酸性溶解。由氟化聚合物和CLG组成的复合材料表现出三维稳定性和显著的疏水性。此外，当使用猪红细胞（RBC）试验进行评价时，未观察到溶血活性。与对照样品相比，用PPZ处理的牛牙本质表现出增加的接触角（疏水性），并且当使用染料渗透研究进行评估时，其抵抗流体渗透。最后，显微硬度评价与PPZ处理的牛牙本质和暴露于酸性挑战表明，处理后的牙本质抗脱矿。与PPZ处理的样品相比，暴露后未处理的对照的硬度显著降低。这项研究代表了一种新的方法，以克服目前的限制，复合材料制备。这些结果是有希望的，以提高复合牙科防腐剂的寿命，并可能在密封剂，清漆，和其他牙科application.Lay总结蛀牙仍然是一个普遍的问题，世界各地。聚合物基复合材料是临床上最常用的牙齿修复材料。这些填充物的寿命是有限的，因为口腔中的条件会削弱用于将复合材料粘合到天然牙齿的粘合剂。目前的研究使用新型聚磷腈（PPZ），具有可调疏水-疏水特性的混合有机-无机大分子来涂覆牙齿表面，以实现与粘合剂更好的相容性，从而提高修复体的寿命。结果表明，PPZ在牙齿上有明显而稳定的吸附，这可能导致更稳定的粘结界面。
AbstractClinically, the use of photo-activated polymer-based dental composites is the preferred method to restore carious teeth due to their esthetics and ease of application. However, the longevity of these resin-based composite tooth restorations can be compromised by the sensitivity of the bonded interface between the composite and the tooth surface. The objective of the current study was to modify the tooth surface with novel fluorinated polyphosphazenes (PPZs), thereby improving the stability of the interface. Binding isotherms of PPZs with collagen (CLG) and hydroxyapatite (HA), two of the primary components of teeth, were established and indicate significant and stable adsorption to the surfaces of these materials. PPZs were also shown to protect CLG against acidic dissolution in a model system. A composite material consisting of the fluorinated polymer and CLG demonstrated three-dimensional stability and significant hydrophobicity. Additionally, no hemolytic activity was observed when evaluated using a porcine red blood cells (RBC) assay. Bovine dentin treated with PPZs demonstrated increased contact angle (hydrophobicity) compared with control samples and resisted fluid penetration when assessed using a dye penetration study. Finally, microhardness evaluation of bovine dentin treated with PPZs and exposed to an acidic challenge showed that treated dentin resisted demineralization. The hardness of the untreated control was significantly reduced after exposure when compared with the PPZ-treated samples. This study represents a novel approach to overcoming the current limitations of composite restorations. These results are promising to improve the longevity of composite dental restorations and may have wider use in sealants, varnishes, and other dental applications.Lay SummaryTooth decay remains a prevalent problem worldwide. Polymer-based composites are the most frequently used tooth restorative used in the clinic. The longevity of these fillings is limited due to conditions in the mouth that can weaken the adhesive used to bond the composite to the natural tooth. The current study uses novel polyphosphazenes (PPZs), hybrid organic-inorganic macromolecules with tunable hydrophilic-hydrophobic properties to coat the tooth surface to achieve better compatibility with the adhesive, thereby improving the longevity of the restoration. Results indicate that PPZs have significant and stable adsorption onto teeth, which may lead to a more stable bonded interface.
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影响因子：
4
作者：
Andrianov AK;Marin A;Fuerst TR
通讯作者：
Fuerst TR
影响因子：
5
作者：
Lim, BS;Ferracane, JL;Condon, JR
通讯作者：
Condon, JR
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DOI：
--
发表时间：
2018
期刊：
影响因子：
--
作者：
Victoria Albright;V. Selin;H. Hlushko;Anbazhagan Palanisamy;A. Marin;A. Andrianov;S. Sukhishvili
通讯作者：
S. Sukhishvili
影响因子：
3.3
作者：
I. Mjör;J. Moorhead;J. Dahl
通讯作者：
I. Mjör;J. Moorhead;J. Dahl
低温制备羟基磷灰石-聚磷氮烷复合材料
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
Y. Greish;P. Brown;J. D. Bender;H. Allcock;S. Lakshmi;C. Laurencin
通讯作者：
C. Laurencin