Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study
Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study
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DOI：
10.1186/s13293-015-0038-6
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发表时间：
2015-11-10
影响因子：
7.9
通讯作者：
Samaan, Zainab
中科院分区：
文献类型：
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作者：
Bawor, Monica;Dennis, Brittany B.;Samaan, Zainab
背景资料：尽管加拿大阿片类药物使用障碍的男性和女性人数不断增加，但在目前的阿片类药物成瘾患者人群中，治疗中的性别特异性问题尚未得到重新研究。我们的目的是评估目前接受美沙酮治疗阿片类药物使用障碍在安大略，加拿大。方法：我们招募了503名参与者接受美沙酮维持治疗的阿片类药物依赖性障碍之间的物质使用，健康和社会功能的性别差异。我们通过尿分析收集了有关人口统计学、治疗特征、精神病史、成瘾严重程度和药物使用模式的数据。我们进行了调整后的单变量分析和logistic回归，以确定影响男性和女性的不同因素。在我们的样本中，54%（n = 266）男性和46%（n = 226）女性，平均年龄38.3岁，不到一半的参与者有工作（35.6%），已婚（31.8%），高中毕业（27.9%）。与男性相比，女性经常出现身体和心理健康问题，有精神疾病家族史，有育儿责任，并开始通过医生处方使用阿片类药物。男性有较高的就业率，吸烟，大麻的使用相比women.Conclusions：我们的研究结果揭示了不同的模式，物质的使用，健康和社会功能的男性和女性目前接受美沙酮治疗阿片类药物成瘾在安大略，加拿大。这些信息可用于制定满足男性和女性个人需求的综合治疗方案，以及告知美沙酮治疗方案，包括专业服务（包括职业咨询，儿童保育和养育援助，医疗援助，关系或家庭暴力咨询等）。并在更大范围内增加其可用性和可及性。
Background: Despite the growing numbers of men and women with opioid use disorder in Canada, sex-specific issues in treatment have not been re-examined in the current population of patients with opioid addiction. We aimed to evaluate sex differences in substance use, health, and social functioning among men and women currently receiving methadone treatment for opioid use disorder in Ontario, Canada.Methods: We recruited 503 participants with opioid dependence disorder receiving methadone maintenance treatment. We collected data on demographics, treatment characteristics, psychiatric history, addiction severity, and drug use patterns through urinalysis. We performed adjusted univariate analyses and logistic regression to identify distinct factors affecting men and women.Results: Among our sample of 54 % (n = 266) men and 46 % women (n = 226) with mean age 38.3 years, less than half of participants were employed (35.6 %) and married (31.8 %) and had completed a high school education (27.9 %). Compared to men, women had frequent physical and psychological health problems, family history of psychiatric illness, and childcare responsibilities and began using opioids through a physician prescription. Men had higher rates of employment, cigarette smoking, and cannabis use compared to women.Conclusions: Our results have revealed different patterns of substance use, health, and social functioning among men and women currently receiving methadone treatment for opioid addiction in Ontario, Canada. This information can be used to develop an integrative treatment regimen that caters to the individual needs of men and women, as well as to inform methadone treatment protocols to include specialized services (including vocational counseling, childcare and parenting assistance, medical assistance, relationship or domestic violence counseling, etc.) and increase their availability and accessibility on a larger scale.