Association of Urine α1-Microglobulin with Kidney Function Decline and Mortality in HIV-Infected Women
Association of Urine α1-Microglobulin with Kidney Function Decline and Mortality in HIV-Infected Women
复制标题
DOI：
10.2215/cjn.03220314
复制
发表时间：
2015-01-01
影响因子：
9.8
通讯作者：
Shlipak, Michael G.
中科院分区：
文献类型：
--
作者：
Jotwani, Vasantha;Scherzer, Rebecca;Shlipak, Michael G.
背景和目的尽管治疗取得了进展，但HIV感染者发生肾功能不全的风险仍然高于未感染者。据推测，尿中1-微球蛋白的水平，近端肾小管功能障碍的生物标志物，将预测肾功能下降和死亡风险在HIV感染和未感染的妇女。从1999年到2000年，使用储存的尿液测量了903名HIV感染和287名未感染妇女的尿1-微球蛋白和肌酐浓度，当替诺福韦的使用率
Background and objectivesDespite advances in therapy, HIV-infected individuals remain at higher risk for kidney dysfunction than uninfected individuals. It was hypothesized that urine levels of 1-microglobulin, a biomarker of proximal tubular dysfunction, would predict kidney function decline and mortality risk in HIV-infected and uninfected women.Design, setting, participants, & measurementsIn the Women's Interagency HIV Study, urine 1-microglobulin and creatinine concentrations were measured in 903 HIV-infected and 287 uninfected women using stored urine from 1999 to 2000, when prevalence of tenofovir use was