Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis.
Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis.
复制标题
DOI：
10.1093/infdis/jir411
复制
发表时间：
2011-11-15
期刊：
影响因子：
--
通讯作者：
Wood R
中科院分区：
文献类型：
--
作者：
Lawn SD;Wood R
在资源有限的环境中接受抗逆转录病毒治疗 (ART) 服务的患者的结核病 (TB) 负担较高，是发病率和死亡率的主要原因，并且与院内传播风险相关。多重耐药性疾病大大加剧了这些风险。在这种临床环境下，结核病的筛查和诊断很困难。然而，在定义高灵敏度、标准化症状筛查工具方面已经取得了进展，该工具可以评估症状的组合，而不是仅仅依赖咳嗽报告。此外，新兴的诊断工具在提供更快速的结核病诊断方面显示出巨大的前景，结核病主要是痰涂片阴性。其中包括基于培养的系统、简化版本的核酸扩增测试（例如 Xpert MTB/RIF 测定）以及尿液中阿拉伯脂甘露聚糖抗原的检测。此外，新的分子诊断现在可以快速检测耐药性。这些工具的进一步开发和实施对于在 ART 服务中快速有效地筛查结核病至关重要，这是患者护理的重要组成部分。
The high burden of tuberculosis (TB) among patients accessing antiretroviral treatment (ART) services in resource-limited settings is a major cause of morbidity and mortality and is associated with nosocomial transmission risk. These risks are greatly compounded by multidrug-resistant disease. Screening and diagnosis of TB in this clinical setting is difficult. However, progress has been made in defining a high-sensitivity, standardized symptom screening tool that assesses a combination of symptoms, rather than relying on report of cough alone. Moreover, newly emerging diagnostic tools show great promise in providing more rapid diagnosis of TB, which is predominantly sputum smear–negative. These include culture-based systems, simplified versions of nucleic acid amplification tests (such as the Xpert MTB/RIF assay), and detection of lipoarabinomannan antigen in urine. In addition, new molecular diagnostics now permit rapid detection of drug resistance. Further development and implementation of these tools is vital to permit rapid and effective screening for TB in ART services, which is an essential component of patient care.
登录
查看更多内容
影响因子：
3.8
作者：
Golub, Jonathan E.;Durovni, Betina;Saraceni, Valeria
通讯作者：
Saraceni, Valeria
DOI：
10.1097/qai.0b013e3181a44ef2
发表时间：
2009-06-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Bassett IV;Wang B;Chetty S;Mazibuko M;Bearnot B;Giddy J;Lu Z;Losina E;Walensky RP;Freedberg KA
通讯作者：
Freedberg KA
影响因子：
3.8
作者：
GILKS, CF;BRINDLE, RJ;WARRELL, DA
通讯作者：
WARRELL, DA
影响因子：
11.8
作者：
Bassett, Ingrid V.;Wang, Bingxia;Freedberg, Kenneth A.
通讯作者：
Freedberg, Kenneth A.
影响因子：
120.7
作者：
ANTONUCCI, G;GIRARDI, E;IPPOLITO, G
通讯作者：
IPPOLITO, G