Effects of genotype x sex interaction on linkage analysis of visual event-related evoked potentials.
Effects of genotype x sex interaction on linkage analysis of visual event-related evoked potentials.
复制标题
基因型 x 性别相互作用对视觉事件相关诱发电位连锁分析的影响。
DOI：
10.1002/gepi.1370170760
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Blangero,J
中科院分区：
文献类型：
--
作者：
Towne,B;Almasy,L;Siervogel,RM;Blangero,J
Autosomal genes contributing to variation in many complex traits are influenced by male or female physiological “environments.” Accounting for such genotype‐by‐sex (G×S) interactions has been shown to be important in quantitative genetic, segregation, and linkage analyses of a number of sexually dimorphic traits. In analyses of data simulated for GAW10, we showed that incorporating sex‐specific variance components into a variance components‐based linkage method increased the power to detect linkage in a trait that exhibited G×S interaction. The goals of this study of data from the Collaborative Study on the Genetics of Alcoholism (COGA) were to screen the event‐related brain potential (ERP) data from COGA participants for G×S interaction, and then to conduct variance components linkage analysis of ERP phenotypes showing evidence of G×S interaction using models incorporating sex‐specific variance components. Significant G×S interaction was found in four ERP phenotypes: N100 measured at occipital leads 1 and 2, and P300 measured at occipital leads 1 and 2. In linkage analyses of these traits, the most significant lod score found was that between N100 occipital lead 1 amplitude and marker D7S490. The peak lod score at the D7S490 locus was 2.45 without sex‐specific variance components, and 3.25 with sex‐specific marker and residual polygenic components.
