HIV Infection Is Associated with Impaired Striatal Function during Inhibition with Normal Cortical Functioning on Functional MRI
HIV Infection Is Associated with Impaired Striatal Function during Inhibition with Normal Cortical Functioning on Functional MRI
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DOI：
10.1017/s1355617715000971
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发表时间：
2015-10-01
影响因子：
2.6
通讯作者：
Emsley, Robin
中科院分区：
文献类型：
--
作者：
du Plessis, Stefan;Vink, Matthijs;Emsley, Robin
本研究的目的是调查艾滋病毒感染对参与抑制随意运动的额叶纹状体系统皮质和皮质下区域的影响。功能性核磁共振（fMRI）研究表明，人类免疫缺陷病毒（HIV）感染与额纹状体功能障碍有关。虽然额纹状体系统在行为抑制中发挥着关键作用，但据我们所知，还没有功能磁共振成像研究调查艾滋病毒对随意运动抑制过程中涉及的系统的潜在影响。总共 17 名未接受过联合抗逆转录病毒治疗 (cART) 的 HIV+ 参与者以及 18 名年龄、性别、种族、教育程度匹配的健康对照者执行了停止信号范例的修改版本。该范式评估了与运动执行、反应性抑制（完全停止）和主动抑制（停止前预期反应减慢）相关的行为以及功能性大脑活动。与健康对照组相比，HIV+参与者在运动执行过程中表现出明显较慢的反应，而他们的主动反应却正常减慢。成功停止后，HIV + 参与者的壳核激活不足很明显，表明反应性抑制期间皮层下功能障碍。 HIV+参与者在主动抑制期间表现出正常的皮质功能。我们的数据提供证据表明，HIV 感染与反应性抑制期间的皮质下功能障碍相关，同时在主动抑制期间伴随着相对正常的高级皮质功能。这表明 HIV 感染可能主要涉及未接受 cART 参与者的基本纹状体介导的控制过程。
The aim of the present study was to investigate the effect of HIV infection on cortical and subcortical regions of the frontal-striatal system involved in the inhibition of voluntary movement. Functional MRI (fMRI) studies suggest that human immunodeficiency virus (HIV) infection is associated with frontostriatal dysfunction. While frontostriatal systems play a key role in behavioral inhibition, there are to our knowledge no fMRI studies investigating the potential impact of HIV on systems involved during the inhibition of voluntary movement. A total of 17 combined antiretroviral therapy (cART) naive HIV+ participants as well as 18 age, gender, ethnic, education matched healthy controls performed a modified version of the stop-signal paradigm. This paradigm assessed behavior as well as functional brain activity associated with motor execution, reactive inhibition (outright stopping) and proactive inhibition (anticipatory response slowing before stopping). HIV+ participants showed significantly slower responses during motor execution compared to healthy controls, whereas they had normal proactive response slowing. Putamen hypoactivation was evident in the HIV+ participants based on successful stopping, indicating subcortical dysfunction during reactive inhibition. HIV+ participants showed normal cortical functioning during proactive inhibition. Our data provide evidence that HIV infection is associated with subcortical dysfunction during reactive inhibition, accompanied by relatively normal higher cortical functioning during proactive inhibition. This suggests that HIV infection may primarily involve basic striatal-mediated control processes in cART naive participants.