Hydro-Expandable Calcium Phosphate Micro/Nano-Particles with Controllable Size and Morphology for Mechanical Ablation
Hydro-Expandable Calcium Phosphate Micro/Nano-Particles with Controllable Size and Morphology for Mechanical Ablation
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DOI：
10.1021/acsanm.1c00285
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发表时间：
2021-04-05
影响因子：
5.9
通讯作者：
Jokerst, Jesse, V
中科院分区：
文献类型：
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作者：
He, Tengyu;Bradley, David G.;Jokerst, Jesse, V
磷酸盐基玻璃是一种被广泛研究的可生物降解材料。然而，当磷酸盐玻璃被制备成微粒子或纳米粒子时，人们对其合成和性能知之甚少。这些玻璃具有良好的生物可降解性和生物相容性。因此，磷酸盐玻璃微/纳米颗粒在药物输送、生物成像、可降解植入物和组织工程方面具有重要的发展潜力。本研究采用溶胶-凝胶和电喷雾相结合的方法制备了组成为（P2O5）(25)-(CaO)（75）的磷酸钙微/纳米颗粒（CPPs）。这种合成方法在控制CPPs的尺寸和形态方面具有很大的灵活性。得到的CPPs平均直径在345 ~ 952 nm之间，具有康乃馨花状、高尔夫球状、苹果状等多种形态。光学显微镜进一步证明，在中性水介质中水化后的前5-10 min内，CPPs的直径平均增加95%，体积平均增加720%。氢膨胀过程伴随着磷和钙的两阶段离子释放。我们建议利用粒子的膨胀来机械地消融组织和破坏细胞。
Phosphate-based glasses are well-studied biodegradable materials in the bulk. However, less is known about the synthesis and properties of phosphate glass when prepared as microparticles or nanoparticles. These glasses have excellent biodegradability and biocompatibility. Therefore, phosphate glass micro/nanoparticles have significant potential for advances in drug delivery, bioimaging, degradable implants, and tissue engineering. In this study, calcium phosphate micro/nanoparticles (CPPs) with the composition (P2O5)(25)-(CaO)(75) were prepared through a combination of the sol-gel and electrospray methods. This synthesis method shows great flexibility in controlling the size and morphology of CPPs. CPPs with an average diameter in the range of 345-952 nm and various morphologies including carnation flower-like, golf-ball-like, and apple-like were obtained. Optical microscopy was further used to demonstrate that the CPPs can have an average size increase of 95% in diameter and 720% in volume within the first 5-10 min of hydration in neutral aqueous media. The hydro-expansion process is accompanied by a two-stage ion release of phosphorus and calcium. We propose to utilize the expansion of the particle to mechanically ablate tissue and destroy cells.