Eukaryotic ribosome biogenesis at a glance
Eukaryotic ribosome biogenesis at a glance
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DOI：
10.1242/jcs.111948
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发表时间：
2013-11-01
影响因子：
4
通讯作者：
Hurt, Ed
中科院分区：
文献类型：
--
作者：
Thomson, Emma;Ferreira-Cerca, Sebastien;Hurt, Ed
核糖体在每个细胞的分子生命中起着关键作用。此外，核糖体的合成是所有细胞过程中最耗能的过程之一。在真核细胞中，核糖体的生物发生需要所有三种RNA聚合酶的协调活性和许多(>；200)瞬时相关的核糖体组装因子的协调工作。核糖体的生物发生是一种受到严格调控的活动，它与其他基本的细胞过程密不可分，包括生长和细胞分裂。此外，最近的研究表明，核糖体生物发生的缺陷与几种遗传性疾病有关。在这篇细胞科学概览文章和随附的海报中，我们总结了关于真核核糖体生物发生的当前知识，重点是酵母模型系统。
Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic cells, ribosome biogenesis requires the coordinated activity of all three RNA polymerases and the orchestrated work of many (>200) transiently associated ribosome assembly factors. The biogenesis of ribosomes is a tightly regulated activity and it is inextricably linked to other fundamental cellular processes, including growth and cell division. Furthermore, recent studies have demonstrated that defects in ribosome biogenesis are associated with several hereditary diseases. In this Cell Science at a Glance article and the accompanying poster, we summarise the current knowledge on eukaryotic ribosome biogenesis, with an emphasis on the yeast model system.