Teeth loss and risk of cancer at 14 common sites in Japanese
Teeth loss and risk of cancer at 14 common sites in Japanese
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DOI：
10.1158/1055-9965.epi-07-2761
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发表时间：
2008-05-01
影响因子：
3.8
通讯作者：
Tajima, Kazuo
中科院分区：
文献类型：
--
作者：
Hiraki, Akio;Matsuo, Keitaro;Tajima, Kazuo
背景：牙齿缺失与多种癌症的较高风险相关。为了阐明牙齿缺失对 14 种常见癌症风险的重要性，我们根据爱知癌症中心医院流行病学研究计划进行了一项大规模病例对照研究。方法：总共招募了 5,240 名癌症受试者和 10,480 名年龄和性别匹配的非癌症对照者。 2000年至2005年新诊断的14种癌症患者作为病例对象，同期新诊断的未患癌症的门诊患者作为对照。牙齿缺失分为四组：第一组，剩余牙齿数量，>= 21；第2组，9至20；第3组，1至8；第 4 组，0。牙齿缺失的影响以 95% 置信区间的比值比 (OR) 进行评估（95% CD 使用条件逻辑回归模型计算，并调整了潜在的混杂因素。结果：剩余牙齿数量减少与头颈部 OR 增加相关（OR，1.68；95% CI，0.88-1.93；P 趋势 = 0.055）、食管（OR， 2.36；95% CI，1.17-4.75；P-趋势 = 0.002）和肺癌（OR，1.54；95% CI，1.05-2.27；P-趋势 = 0.027）。结论：在调整潜在的混杂因素后，我们发现牙齿缺失与头颈癌、食管癌和肺癌的风险之间存在显着的正相关。研究结果表明，旨在保护牙齿的预防措施可能会降低患这些癌症的风险。
Background: Tooth loss has been associated with a higher risk of several types of cancer. To clarify the significance of tooth loss to the risk of 14 common cancers, we conducted a large-scale, case-control study based on the Hospital-based Epidemiologic Research Program at Aichi Cancer Center.Methods: A total of 5,240 cancer subjects and 10,480 age- and sex-matched noncancer controls were recruited. Patients with 14 types of cancer newly diagnosed from 2000 to 2005 were eligible as case subjects, and new outpatients without cancer in the same time period were eligible as controls. Tooth loss was categorized into four groups: group 1, number of remaining teeth, >= 21; group 2, 9 to 20; group 3, 1 to 8; and group 4, 0. The effect of tooth loss was assessed as odds ratios (OR) with 95% confidence intervals (95% CD calculated with conditional logistic regression models, with adjustment for potential confounders.Results: A decreased number of remaining teeth was associated with increased OR of head and neck (OR, 1.68; 95% CI, 0.88-1.93; P-trend = 0.055), esophageal (OR, 2.36; 95% CI, 1.17-4.75; P-trend = 0.002), and lung (OR, 1.54; 95% CI, 1.05-2.27; P-trend = 0.027) cancers.Conclusions: We showed a significant positive association between tooth loss and the risk of head and neck, esophageal, and lung cancers after adjustment for potential confounding factors. The findings indicate that preventive efforts aimed at the preservation of teeth may decrease the risk of these cancers.