Non-light-chain immunoglobulin amyloidosis: time to expand or refine the spectrum to include light+heavy chain amyloidosis?
Non-light-chain immunoglobulin amyloidosis: time to expand or refine the spectrum to include light+heavy chain amyloidosis?
复制标题
非轻链免疫球蛋白淀粉样变性：是时候扩大或细化谱系以包括轻重链淀粉样变性了吗？
作者：
M. Picken
在各种系统性淀粉样变性中，源自免疫球蛋白轻链（AL）的沉积物占病例的85%。在本期中，纳斯尔等人。报告16例肾重链和轻+重链淀粉样变性，并与肾轻链淀粉样变性进行比较。虽然需要更多的研究来阐明重链和轻+重链淀粉样变性，但作者的一些观察结果表明了重要的实际意义，包括临床表现、预后和病理诊断的差异。
Among the various systemic amyloidoses, deposits derived from the immunoglobulin light chain (AL) account for 85% of cases. In this issue, Nasr et al. report 16 cases of renal heavy and light+heavy chain amyloidosis and compare them with renal light chain amyloidosis. While additional studies are needed to shed light on the heavy and light+heavy chain amyloidoses, several observations by the authors suggest important practical implications, including differences in clinical picture, prognosis and pathologic diagnosis.