Expression of E-selectin ligands on circulating tumor cells: cross-regulation with cancer stem cell regulatory pathways?
Expression of E-selectin ligands on circulating tumor cells: cross-regulation with cancer stem cell regulatory pathways?
复制标题
E-选择素配体在循环肿瘤细胞上的表达：与癌症干细胞调控途径的交叉调控？
DOI：
10.3389/fonc.2012.00103
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发表时间：
2012
影响因子：
4.7
通讯作者：
Benencia F
中科院分区：
文献类型：
--
作者：
Burdick MM;Henson KA;Delgadillo LF;Choi YE;Goetz DJ;Tees DF;Benencia F
虽然在对抗癌症方面已经取得了重大进展，但尚未开发成功的治疗策略来对抗那些已经转移到远处器官的肿瘤。对癌症扩散的分子机制的不良表征是设计针对晚期疾病的预测性诊断和有效临床干预的主要障碍。在血行转移中，广泛怀疑循环肿瘤细胞（CTC）表达特异性粘附分子，其主动启动与靶器官的血管壁内衬的血管内皮的接触。这种“拴系”由CTC表达的配体介导，所述配体与内皮细胞表达的E-选择素结合。然而，目前尚不清楚CTC上功能性E-选择素配体的表达是否与癌症干细胞调节或维持途径相关，特别是上皮-间充质转化和相反的间充质-上皮转化。在这篇假说和理论文章中，我们探讨了这些机制对转移过程中选择素配体介导CTC运输的动态调节的潜在作用。
Although significant progress has been made in the fight against cancer, successful treatment strategies have yet to be developed to combat those tumors that have metastasized to distant organs. Poor characterization of the molecular mechanisms of cancer spread is a major impediment to designing predictive diagnostics and effective clinical interventions against late stage disease. In hematogenous metastasis, it is widely suspected that circulating tumor cells (CTCs) express specific adhesion molecules that actively initiate contact with the vascular endothelium lining the vessel walls of the target organ. This “tethering” is mediated by ligands expressed by CTCs that bind to E-selectin expressed by endothelial cells. However, it is currently unknown whether expression of functional E-selectin ligands on CTCs is related to cancer stem cell regulatory or maintenance pathways, particularly epithelial-to-mesenchymal transition and the reverse, mesenchymal-to-epithelial transition. In this hypothesis and theory article, we explore the potential roles of these mechanisms on the dynamic regulation of selectin ligands mediating CTC trafficking during metastasis.