Insights into Antimicrobial Peptides from Spiders and Scorpions.
Insights into Antimicrobial Peptides from Spiders and Scorpions.
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DOI：
10.2174/0929866523666160511151320
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发表时间：
2016
影响因子：
1.6
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Wang X;Wang G
蜘蛛和蝎子的毒液含有多种化合物。来自这些生物体的抗菌肽（AMP）首次发现于20世纪90年代。截至2015年5月，在抗菌肽数据库（http：//aps.unmc.edu/AP）中有42种蜘蛛AMP和63种蝎子AMP。这些肽已被证明对细菌、真菌、病毒和寄生虫具有广谱或窄谱活性。此外，它们可能对癌细胞、昆虫和红细胞有毒。为了深入了解这种活性谱，本文讨论了蜘蛛和蝎子AMP的发现，分类，结构和活性关系，生物信息学分析，以及潜在的应用。我们的分析表明，在线性肽的情况下，蜘蛛使用富含甘氨酸和螺旋肽模型进行防御，而蝎子使用两种不同的螺旋肽模型，具有不同的氨基酸组成，发挥所观察到的抗菌活性和溶血毒性。我们的结构生物信息学研究提高了该领域的知识，可用于设计更具选择性的肽来对抗肿瘤，寄生虫和病毒。
The venoms of spiders and scorpions contain a variety of chemical compounds. Antimicrobial peptides (AMPs) from these organisms were first discovered in the 1990s. As of May 2015, there were 42 spider’s and 63 scorpion’s AMPs in the Antimicrobial Peptide Database (http://aps.unmc.edu/AP). These peptides have demonstrated broad or narrow-spectrum activities against bacteria, fungi, viruses, and parasites. In addition, they can be toxic to cancer cells, insects and erythrocytes. To provide insight into such an activity spectrum, this article discusses the discovery, classification, structure and activity relationships, bioinformatics analysis, and potential applications of spider and scorpion AMPs. Our analysis reveals that, in the case of linear peptides, spiders use both glycine-rich and helical peptide models for defense, whereas scorpions use two distinct helical peptide models with different amino acid compositions to exert the observed antimicrobial activities and hemolytic toxicity. Our structural bioinformatics study improves the knowledge in the field and can be used to design more selective peptides to combat tumors, parasites, and viruses.