Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction
Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction
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DOI：
10.1016/j.jacc.2005.11.026
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发表时间：
2006-01-17
影响因子：
24
通讯作者：
Fontaine, JM
中科院分区：
文献类型：
--
作者：
Bloomfield, DM;Bigger, JT;Fontaine, JM
目的 本研究假设微伏级T波电交替（MTWA）可改进对植入型心律转复除颤器（ICD）预防性治疗患者的选择，尤其通过识别不太可能受益的患者。背景 许多左心室功能障碍患者现在符合预防性ICD的使用条件，但大多数符合条件的患者并未受益；已有人提出MTWA检测可改进患者的选择。方法 我们的研究在美国11个临床中心进行。如果患者左心室射血分数（LVEF）……
OBJECTIVES This study hypothesized that microvolt T-wave alternans (MTWA) improves selection of patients for implantable cardioverter-defibrillator (ICD) prophylaxis, especially by identifying patients who are not likely to benefit.BACKGROUND Many patients with left ventricular dysfunction are now eligible for prophylactic ICDs, but most eligible patients do not benefit; MTWA testing has been proposed to improve patient selection.METHODS Our study was conducted at 11 clinical centers in the U.S. Patients were eligible if they had a left ventricular ejection fraction (LVEF)