Detectable Viral Load May Be Associated with Increased Pain Sensitivity in Persons Living with HIV: Preliminary Findings
Detectable Viral Load May Be Associated with Increased Pain Sensitivity in Persons Living with HIV: Preliminary Findings
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DOI：
10.1093/pm/pnx057
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发表时间：
2017-12-01
期刊：
影响因子：
3.1
通讯作者：
Merlin, Jessica S.
中科院分区：
文献类型：
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作者：
Goodin, Burel R.;Owens, Michael A.;Merlin, Jessica S.
Objective.动物模型先前已经表明，艾滋病毒与痛觉过敏，或对疼痛刺激的敏感性增加有关。目前还缺乏确定这一发现是否适用于人类的努力。在艾滋病毒感染者（PLWH）中，那些具有可检测病毒载量的人可能是疼痛敏感性升高的最大风险。假设与没有可检测病毒载量的PLWH和没有HIV的健康对照相比，具有可检测病毒载量的PLWH对疼痛刺激更敏感。共招募了47名PLWH和50名社区居住的健康成年人（对照组）。参与者完成了一个定量的感觉测试协议，以评估阈值，耐受性和时间总和疼痛的机械和热刺激。从病历中收集最新病毒载量，如果计数大于50拷贝/mL血液，则认为病毒载量可检出。47例PLWH中11例（23.4%）检出病毒载量，病毒载量中位数为10,200拷贝/mL。病毒载量可检测的PLWH表现出对机械刺激的疼痛阈值显著降低（F-2，F-89 = 3.15，P = 0.049），热痛耐受性显著降低（F-2，F-89 = 3.38，P = 0.039），48 ℃时热痛的时间总和显著增加（F-2，F-89 = 10.66，P
Objective. Animal models have previously shown that HIV is associated with hyperalgesia, or heightened sensitivity to painful stimuli. Efforts to determine whether this finding translates to humans are presently lacking. Among persons living with HIV (PLWH), those with detectable viral loads may be at greatest risk for heightened pain sensitivity. It was hypothesized that PLWH with detectable viral loads would be more sensitive to painful stimuli compared with PLWH without detectable viral loads and healthy controls without HIV.Design. A total of 47 PLWH and 50 community-dwelling, healthy adults without HIV (controls) were recruited. Participants completed a quantitative sensory testing protocol to assess threshold, tolerance, and temporal summation in response to painful mechanical and heat stimuli. Most recent viral load was collected from medical records, and viral load was considered detectable if the count was greater than 50 copies/mL of blood. Of the 47 PLWH, 11 (23.4%) had detectable viral loads, the median viral load count was 10,200 copies/mL.Results. PLWH with detectable viral loads demonstrated significantly lower pain thresholds for mechanical stimuli (F-2,F-89 = 3.15, P = 0.049), significantly lower heat pain tolerances (F-2,F-89 = 3.38, P = 0.039), and significantly greater temporal summation of heat pain at 48 degrees C (F-2,F-89 = 10.66, P