Sleep patterns and daytime sleepiness in adolescents and young adults with Williams syndrome
Sleep patterns and daytime sleepiness in adolescents and young adults with Williams syndrome
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DOI：
10.1111/j.1365-2788.2008.01140.x
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发表时间：
2009-02-01
影响因子：
3.6
通讯作者：
Dykens, E. M.
中科院分区：
文献类型：
--
作者：
Goldman, S. E.;Malow, B. A.;Dykens, E. M.
睡眠障碍在神经发育障碍患者中很常见，可能会对白天的功能产生不利影响。据报道，患有威廉姆斯综合症的儿童会出现睡眠障碍。然而，尚未进行任何研究来确定这些问题是否会持续到青春期和成年期。这项研究检查了 23 名年龄为 25.5 (8.0) 岁的威廉姆斯综合征青少年和成人的夜间睡眠模式和白天嗜睡情况[平均值 (SD)]。访谈者进行的睡眠问卷用于评估夜间睡眠行为和白天嗜睡。腕部活动记录仪用于评估睡眠模式。尽管我们样本中的个体平均晚上在床上躺了 9 个小时，但白天嗜睡和睡眠中断的测量结果很常见，并且与其他患有神经发育障碍的人群相当。这些措施包括睡眠效率降低[74.4 (7.0)%]，睡眠潜伏期延长[37.7 (37.3) 分钟]，入睡后觉醒时间增加[56.1 (17.6) 分钟]，以及运动和碎片指数升高[14.3 (4.6)]。发现患有威廉姆斯综合征的青少年和年轻人尽管平均晚上在床上待9 小时，但仍感到困倦。讨论了睡眠中断的相关原因和未来多导睡眠图评估的影响。
Sleep disorders are common in individuals with neurodevelopmental disorders and may adversely affect daytime functioning. Children with Williams syndrome have been reported to have disturbed sleep; however, no studies have been performed to determine if these problems continue into adolescence and adulthood.This study examined overnight sleep patterns and daytime sleepiness in 23 adolescents and adults with Williams syndrome age 25.5 (8.0) years [mean (SD)]. Interviewer-administered sleep questionnaires were used to evaluate nighttime sleep behaviours and daytime sleepiness. Wrist actigraphy was used to evaluate sleep patterns.Although individuals in our sample averaged 9 h in bed at night, daytime sleepiness and measures of sleep disruption were common and comparable to those of other populations with neurodevelopmental disorders. These measures included reduced sleep efficiency [74.4 (7.0)%] with prolonged sleep latency [37.7 (37.3) min], increased wake time after sleep onset [56.1 (17.6) min], and an elevated movement and fragmentation index [14.3 (4.6)].Adolescents and young adults with Williams syndrome were found to be sleepy despite averaging 9 h in bed at night. Implications are discussed for associated causes of sleep disruption and future polysomnographic evaluation.