Mucosal immunity: integration between mother and the breast-fed infant
Mucosal immunity: integration between mother and the breast-fed infant
复制标题
DOI：
10.1016/s0264-410x(03)00338-4
复制
发表时间：
2003-07-28
期刊：
影响因子：
5.5
通讯作者：
Brandtzaeg, P
中科院分区：
文献类型：
--
作者：
Brandtzaeg, P
泌乳乳腺是整体粘膜免疫系统的一部分，局部产生抗体，主要由分泌性免疫球蛋白A （SIgA）组成。这些抗体通常反映了普通肠道和呼吸道病原体对粘膜相关淋巴组织（MALT）的抗原刺激。因此，母乳中的抗体对母亲环境中的传染性病原体具有高度针对性，这些病原体是婴儿出生后不久可能遇到的。因此，母乳喂养代表了母亲和孩子巧妙的免疫整合。粘膜是大多数感染因子的入口，新生儿期在这方面尤为关键。黏膜病原体是5岁以下儿童的主要杀手，每年造成1400多万人死亡。发展中国家每年仅腹泻一项就造成500万儿童死亡。流行病学数据表明，母乳喂养的儿童死于腹泻的风险可降低14-24倍。在工业化国家，有益的临床效果也很明显，甚至在中耳炎和急性下呼吸道感染等相对常见的疾病方面也是如此。2003爱思唯尔科学有限公司版权所有。
Lactating mammary glands are part of an integrated mucosal immune system with local production of antibodies, mainly consisting of secretory immunoglobulin A (SIgA). These antibodies generally reflect antigenic stimulation of mucosa-associated lymphoid tissue (MALT) by common intestinal and respiratory pathogens. Antibodies in breast milk are thus highly targeted against infectious agents in the mother's environment, which are those likely to be encountered by the infant shortly after birth. Therefore, breast-feeding represents an ingenious immunological integration of mother and child. The mucosae are favored as portals of entry by most infectious agents, and the neonatal period is particularly critical in this respect. Mucosal pathogens are a major killer of children below the age of 5 years, being responsible for more than 14 million deaths annually. Diarrheal disease alone claims a toll of 5 million children per year in the developing countries. Epidemiological data suggest that the risk of dying from diarrhea could be reduced 14-24 times in breast-fed children. A beneficial clinical effect is also apparent in the industrialized world, even in relation to relatively common diseases such as otitis media and acute lower respiratory tract infections. (C) 2003 Elsevier Science Ltd. All rights reserved.