EchoLOCATION: an in silico analysis of the subcellular locations of Escherichia coli proteins and comparison with experimentally derived locations
EchoLOCATION: an in silico analysis of the subcellular locations of Escherichia coli proteins and comparison with experimentally derived locations
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DOI：
10.1093/bioinformatics/btn596
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发表时间：
2009-01-15
期刊：
影响因子：
5.8
通讯作者：
Thomas, Gavin H.
中科院分区：
文献类型：
--
作者：
Horler, Richard S. P.;Butcher, Andrew;Thomas, Gavin H.
EchoLOCATION是一个数据库，提供了大肠杆菌K-12蛋白亚细胞位置的综合分析。通过整合来自一系列公开可用算法的数据并结合广泛的实验文献来预测位置。这些数据可以通过多种方式进行搜索，并可以生成用于分析的亚细胞蛋白质组列表。实验证据支持超过500个包膜蛋白（周质，内膜和外膜）的位置。通过分析计算机预测和实验数据之间的差异，我们提供了亚细胞预测算法目前不准确的蛋白质类型的分析。
EchoLOCATION is a database that provides a comprehensive analysis of the subcellular locations of Escherichia coli K-12 proteins. Locations are predicted by integrating data from a range of publicly available algorithms combined with extensive curation of experimental literature. The data can be searched in a variety of ways and can generate lists of subcellular proteomes for analysis. Experimental evidence supports the locations of over 500 envelope proteins (periplasm, inner and outer membrane). From analysis of disagreements between in silico predictions and experimental data, we provide an analysis of protein types where subcellular prediction algorithms are currently not accurate.