Human immune responses during schistosomiasis mansoni.
Human immune responses during schistosomiasis mansoni.
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DOI：
10.1590/s0037-86821992000200006
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发表时间：
1992-04-01
影响因子：
2
通讯作者：
Colley, D G
中科院分区：
文献类型：
--
作者：
Gazzinelli, G;Colley, D G
血吸虫病患者的免疫反应研究似乎相对于当前的技术进步而取得了进展，尽管在这种宿主/寄生虫系统中无法进行体内操作是可以理解的。最常强调的是在再感染/未再感染、肠道/肝脾、高/低感染强度、流行区感染/未感染以及感染/未感染母亲所生的患者群体之间进行免疫学比较。基于这些类型的比较，可以对这种慢性暴露条件下的免疫学事件做出合理的解释。现在正在考虑一些观察结果的免疫机制，虽然其中一些必须带回实验模型进行进一步的基于操作的分析，新的技术发展继续在该领域提供帮助/提出问题的能力，这些问题可能有助于我们的理解，使这些知识可以应用于塑造疫苗开发的发展方法和目标降低发病率。
Studies of immune responses as they occur in patients with schistosomiasis appear to progress relative to cUrrent technological advances, and to advance despite the understandable inability to pursue in vivo manipulations in this host/parasite system. Emphasis is most often placed on making immunological comparisons between such patient groups as reinfected/non-reinfected, intestinal/hepatosplenic, high/low intensities of infection, infected/uninfected within endemic areas, and those born of infected/uninfected mothers. Based on these types of comparisons, reasonable conjectures can be made regarding the immunological occurrences during this chronic exposure condition. Some consideration is now being given to the immune mechanisms of some of the observations made, and while some of these must then be carried back to experimental models for further manipulation-based analysis, new technological developments continue to assist in the field/bench ability to ask questions that might assist our understanding to a point where this knowledge can be applied to shaping developmental approaches to vaccine development and the goal of alleviating morbidity.