Corneal Reshaping and Wavefront Aberrations During Overnight Orthokeratology
Corneal Reshaping and Wavefront Aberrations During Overnight Orthokeratology
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夜间角膜塑形术期间的角膜重塑和波前像差
DOI：
10.1097/icl.0000000000000031
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发表时间：
2014-05-01
影响因子：
2.3
通讯作者：
Lu, Fan
中科院分区：
文献类型：
--
作者：
Lian, Yan;Shen, Meixiao;Lu, Fan
目的：目的观察夜间近视角膜塑形（OK）透镜配戴30天后垂直子午线和水平子午线角膜厚度及波前像差的变化。方法：16名受试者（11名女性，5名男性，26.3 ± 3.2岁）入组并配戴OK镜片。在基线和第1、7和30天，使用长扫描深度光学相干断层扫描测量水平和垂直子午线的角膜厚度分布。测量6 mm瞳孔的角膜和眼WA，并确定散光、彗差、球面像差（SA）和总高阶像差（HOA）的均方根（RMS）。结果如下：在30天的时间内，中央角膜变薄的水平和垂直子午线，而角膜增厚发生在颞，鼻，和下中周边。相比之下，角膜在中周边上级变薄。在研究期间，散光、SA、彗差和正水平彗差的RMS显著增加。OK后角膜中央厚度变化差与总HOA和SA的角膜和眼RMS变化均呈显著正相关（r范围：0.281~0.492，P
Purpose: To investigate changes of corneal thickness at the vertical and horizontal meridians and of wavefront aberrations (WA) over a 30-day period of overnight myopia orthokeratology (OK) lens wear. Methods: Sixteen subjects (11 women, 5 men, 26.3 +/- 3.2 years) were enrolled and fitted for OK lenses. Long scan depth optical coherence tomography was used to measure corneal thickness profiles at both horizontal and vertical meridians at baseline and on days 1, 7, and 30 days. Corneal and ocular WA of a 6-mm pupil were measured and the root-mean-square (RMS) of the astigmatism, coma, spherical aberration (SA), and total higher-order aberrations (HOAs) were determined. Results: During the 30-day period, the central cornea thinned in the horizontal and vertical meridians, whereas corneal thickening occurred in the temporal, nasal, and inferior mid-peripheries. In contrast, the cornea thinned in the mid-peripheral superior. There were significant increases in RMS for astigmatism, SA, coma, and positive horizontal coma during the study period. After OK, there were significant positive correlations between the midperipheral-central thickness change difference and the changes in corneal and ocular RMS of total HOAs and SA (r range: 0.281 to 0.492, P