Chemokines and the microenvironment in neuroectodermal tumor-host interaction.
Chemokines and the microenvironment in neuroectodermal tumor-host interaction.
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DOI：
10.1016/j.semcancer.2008.11.002
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发表时间：
2009-04
影响因子：
14.5
通讯作者：
Herlyn D
中科院分区：
文献类型：
--
作者：
Somasundaram R;Herlyn D
趋化因子和趋化因子受体在免疫稳态和监视中起重要作用。趋化因子和/或趋化因子受体的改变或缺陷表达可导致疾病状态，包括自身免疫性病症或癌症。来自胶质母细胞瘤、黑素瘤和神经母细胞瘤的肿瘤分泌高水平的趋化因子，所述趋化因子可促进肿瘤生长和进展或诱导肿瘤微环境中存在的基质细胞产生细胞因子或趋化因子，所述细胞因子或趋化因子进而可调节血管生成、肿瘤生长和转移。另一方面，由肿瘤或基质细胞分泌的趋化因子也可以吸引白细胞，如树突细胞、巨噬细胞、嗜中性粒细胞和淋巴细胞，其可以下调肿瘤生长。通过趋化因子将免疫效应细胞吸引到肿瘤部位来限制肿瘤生长和进展的新疗法可能是成功治疗癌症的关键，尽管这种方法可能受到趋化因子可能的肿瘤生长刺激作用的阻碍。
Chemokines and chemokine receptors play an important role in immune homeostasis and surveillance. Altered or defective expression of chemokines and/or chemokine receptors could lead to a disease state including autoimmune disorder or cancer. Tumors from glioblastoma, melanoma, and neuroblastoma secrete high levels of chemokines that can promote tumor growth and progression or induce stromal cells present in the tumor microenvironment to produce cytokines or chemokines which, in turn, can regulate angiogenesis, tumor growth, and metastasis. On the other hand, chemokines secreted by tumor or stromal cells can also attract leukocytes such as dendritic cells, macrophages, neutrophils, and lymphocytes which may downmodulate tumor growth. New therapies that are aimed at limiting tumor growth and progression by attracting immune effector cells to the tumor site with chemokines may hold the key to the successful treatment of cancer, although this approach may be hampered by possible tumor growth-stimulating effects of chemokines.
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