Candidate Gene Association Study of BMI-Related Loci, Weight, and Adiposity in Old Age
Candidate Gene Association Study of BMI-Related Loci, Weight, and Adiposity in Old Age
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DOI：
10.1093/gerona/gls227
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发表时间：
2013-06-01
影响因子：
5.1
通讯作者：
Harris, Tamara B.
中科院分区：
文献类型：
--
作者：
Murphy, Rachel A.;Nalls, Michael A.;Harris, Tamara B.
大多数全基因组关联研究仅限于中年人群。目前尚不清楚单核苷酸多态性（SNPs）和肥胖之间的关联是否在老年持续存在。我们的目的是将10个体重指数（BMI）相关的SNP与健康ABC和AGES-Reykjavik的体重，BMI，%脂肪，内脏和皮下脂肪组织相关，包括4，846名欧洲肥胖患者和1，139名65岁以上的非洲裔美国人。使用来自候选SNP的效应估计来缩放SNP。在健康ABC中，GNPDA 2附近的SNP与体重和SAT面积适度相关（p = .008，p = .001）。在AGES-Reykjavik研究中，风险评分（按比例缩放的SNP总和）与体重、BMI和SAT面积相关（所有p <0.0001），但GNPDA 2和风险评分均与体重、BMI、内脏脂肪组织、皮下脂肪组织或%脂肪无关。在非裔美国人中，SEC 16 B附近的SNP与体重弱相关（p = 0.04）。在这个老年人样本中，没有BMI相关的SNP与体重或肥胖相关。
Most genome-wide association studies are confined to middle-aged populations. It is unclear whether associations between single nucleotide polymorphisms (SNPs) and obesity persist in old age. We aimed to relate 10 body mass index (BMI)-associated SNPs to weight, BMI, % fat, visceral and subcutaneous adipose tissue in Health ABC and AGES-Reykjavik comprising 4,846 individuals of European Ancestry, and 1,139 African Americans over age 65. SNPs were scaled using effect estimates from candidate SNPs. In Health ABC, a SNP near GNPDA2 was modestly associated with weight and SAT area (p = .008, p = .001). Risk score (sum of scaled SNPs) was associated with weight, BMI, and SAT area (p < .0001 for all), but neither GNPDA2 nor risk score was associated with weight, BMI, visceral adippose tissue, subcutaneous adipose tissue, or % fat in AGES-Reykjavik. In African Americans, a SNP near SEC16B was weakly associated with weight (p = .04). In this sample of older adults, no BMI-associated SNPs were associated with weight or adiposity.