Investigation of the large-scale functional brain networks modulated by acupuncture
Investigation of the large-scale functional brain networks modulated by acupuncture
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针灸调节的大规模功能性脑网络的研究
DOI：
10.1016/j.mri.2011.04.009
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发表时间：
2011-09-01
影响因子：
2.5
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Feng, Yuanyuan;Bai, Lijun;Tian, Jie
以往的神经影像学研究主要集中在涉及针灸急性效应的神经活动上。考虑到针灸可以产生持久的效果，一些研究人员开始关注针灸对静息大脑的持续影响。这些研究大多采用基于一个或几个预先选择的脑区域的功能连接分析，并证明了针刺的特定效果背后的各种功能引导的脑网络。很少有人研究这些大脑网络是如何在全脑水平上相互作用的。在这项研究中，我们试图研究针刺ST36 （ACUP）与邻近非穴位针刺（SHAM）后全脑功能的相关性。我们将整个大脑划分为90个区域，并针对每种情况构建了脑功能网络。然后，我们检查了网络枢纽，并确定了两种情况之间功能相关性的统计显着差异。ACUP而非SHAM后，杏仁核、海马体和前扣带回等边缘/旁边缘区域成为网络枢纽。对于直接比较，ACUP与SHAM的相关性增加主要与边缘/副边缘和皮层下区域（如岛、杏仁核、前扣带回和丘脑）有关，而相关性降低主要与感觉和额叶皮层有关。两种情况下的异质性调节模式可能与针刺的功能特异性调节作用有关。这些初步发现可能有助于我们更好地了解针灸对整个静息大脑的长期影响，以及针灸背后的神经生理机制。(C) 2011爱思唯尔公司版权所有。
Previous neuroimaging studies have primarily focused on the neural activities involving the acute effects of acupuncture. Considering that acupuncture can induce long-lasting effects, several researchers have begun to pay attention to the sustained effects of acupuncture on the resting brain. Most of these researchers adopted functional connectivity analysis based on one or a few preselected brain regions and demonstrated various function-guided brain networks underlying the specific effect of acupuncture. Few have investigated how these brain networks interacted at the whole-brain level. In this study, we sought to investigate the functional correlations throughout the entire brain following acupuncture at acupoint ST36 (ACUP) in comparison with acupuncture at nearby nonacupoint (SHAM). We divided the whole brain into 90 regions and constructed functional brain network for each condition. Then we examined the network hubs and identified statistically significant differences in functional correlations between the two conditions. Following ACUP, but not SHAM, the limbic/paralimbic regions such as the amygdala, hippocampus and anterior cingulate gyrus emerged as network hubs. For direct comparisons, increased correlations for ACUP compared to SHAM were primarily related with the limbic/paralimbic and subcortical regions such as the insula, amygdala, anterior cingulate gyrus, and thalamus, whereas decreased correlations were mainly related with the sensory and frontal cortex. The heterogeneous modulation patterns between the two conditions may relate to the functional specific modulatory effects of acupuncture. The preliminary findings may help us to better understand the long-lasting effects of acupuncture on the entire resting brain, as well as the neurophysiological mechanisms underlying acupuncture. (C) 2011 Elsevier Inc. All rights reserved.