Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study
Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study
复制标题
DOI：
10.1016/j.psychres.2018.08.039
复制
发表时间：
2018-11-01
影响因子：
11.3
通讯作者：
Carra, Giuseppe
中科院分区：
文献类型：
--
作者：
Bartoli, Francesco;Crocamo, Cristina;Carra, Giuseppe
以前的研究已经假设血清尿酸作为精神障碍和相关行为的标志，可能是因为它与嘌呤能传递和抗氧化活性有关。我们测试了99名患有严重情感障碍的个体的血尿酸水平与特定的行为和临床特征的关系。受试者使用Kessler心理苦恼量表、哥伦比亚自杀严重程度评定量表、改良的公开攻击量表和Barratt冲动量表进行评估和访谈。我们发现，心理困扰和自杀意念的严重程度与较低的血尿酸水平有关。另一方面，言语攻击性和暴力史与较高的血尿酸水平有关。然而，根据线性回归分析，没有与血尿酸独立相关的行为和临床特征。血尿酸水平受肌酐和BMI的影响，可能还受白细胞计数和性别的影响。尽管有一些局限性，但这些结果表明，行为/临床特征与血尿酸的变化无关，而血尿酸的变化似乎更多地归因于特定的生化和代谢参数。然而，嘌呤能系统在不同精神障碍和行为异常中的作用值得进一步研究。
Previous research has hypothesized a role for serum uric acid as a marker of mental disorders and related behaviors, possibly due to its link with purinergic transmission and antioxidant activity. We tested the association of serum uric acid levels with specific behavioral and clinical characteristics in 99 individuals suffering from major affective disorders. Subjects were assessed and interviewed using the Kessler Psychological Distress Scale, the Columbia-Suicide Severity Rating Scale, the Modified Overt Aggression Scale, and the Barratt Impulsiveness Scale. We found that psychological distress and suicidal ideation severity were associated with lower uric acid serum levels. On the other hand, verbal aggression and history of violence were associated with higher levels of serum uric acid. However, according to linear regression analyses, there were no behavioral and clinical characteristics independently associated with serum uric acid. Serum uric acid levels were influenced by creatinine and BMI, as well as, possibly, by white blood cells count and gender. Despite some limitations, these results suggest that no behavioral / clinical features are associated with variations of serum uric acid, which rather seem attributable to specific biochemical and metabolic parameters. Nevertheless, the role of purinergic system in different mental disorders and behavioral abnormalities, deserves further research.