In vivo studies with covalent conjugates of cobra venom factor and monoclonal antibodies to human tumors.
In vivo studies with covalent conjugates of cobra venom factor and monoclonal antibodies to human tumors.
复制标题
眼镜蛇毒因子和人类肿瘤单克隆抗体共价缀合物的体内研究。
DOI：
10.1007/978-3-642-70385-0_104
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Morgan,AC
中科院分区：
文献类型：
--
作者：
Vogel,CW;Wilkie,SD;Morgan,AC
眼镜蛇毒因子（CVF）是一种无毒的糖蛋白，分子量约为140000。CVF是C3 b的功能类似物，C3 b是补体第三组分的活化形式。与C3 B一样，CVF在血清中与补体旁路途径的因子B形成一种酶，即C3/C5转化酶[1]。CVF依赖性酶非常稳定，并且对对照蛋白的失活具有抗性。因此，一旦酶形成，它就会持续激活C3和C5。
Cobra venom factor (CVF) is a nontoxic glycoprotein withMr ~140 000, obtained from cobra venom. CVF is a functional analog of C3b, the activated form of the third component of complement. Like C3b, CVF forms in serum with factor B of the alternative complement pathway an enzyme, the C3/C5 convertase [1]. The CVFdependent enzyme is very stable and resistant to inactivation by control proteins. Therefore, once the enzyme is formed, it continuously activates C3 and C5.