Characteristics of Patients Undergoing Endoscopic Retrograde Cholangiopancreatography for Sphincter of Oddi Disorders.
Characteristics of Patients Undergoing Endoscopic Retrograde Cholangiopancreatography for Sphincter of Oddi Disorders.
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DOI：
10.1016/j.cgh.2021.03.008
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发表时间：
2022-03
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影响因子：
--
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方法本研究比较了两项针对疑似 SOD 患者进行 ERCP 前瞻性研究的患者。参考人群是在EPISOD试验中随机分配的患者，其入组标准、方法和结果已公布。 1 比较人群是持续的、纵向的 RESPOnD 队列（有关入组标准，请参阅补充表 1）。 RESPOnD 的关键纳入标准是针对疑似 SOD 指征的初治患者进行 ERCP 的表现。出于描述目的并与 SOD 的罗马 IV 定义保持一致，RESPOND 中的受试者分为有和没有诊断特发性复发性急性胰腺炎（iRAP；或胰腺 SOD）的受试者。 3 iRAP 由医生报告定义，不需要 2 次单独的发作符合修订后的亚特兰大标准或复发性急性胰腺炎的其他专家标准。 4 有关其他方法，请参阅补充方法。结果在 2018 年 1 月至 2020 年 6 月期间，将参加 RESPOnD 的前 140 名受试者与来自 EPISOD 的随机队列 (n= 214) 进行了比较。使用罗马 III 定义，5 个 RESPOnD 亚型包括胆道 I 型 (n = 21)、II 型 (n = 44)、III 型 (n = 17)、胰腺 (n = 48) 和未知 (n = 10)。与EPISOD相比，参加RESPOND的受试者年龄明显较大（补充表2），大多数（56％）胆道SOD患者的至少1项肝脏化学指标增加了2倍以上，导管扩张较少见（表1）。
MethodsThis study compares patients from 2 prospective studies of ERCP performed for patients with suspected SOD. The reference population was patients randomized in the EPISOD trial, the enrollment criteria, methods, and results of which have been published. 1 The comparison population is the ongoing, longitudinal RESPOnD cohort (see Supplementary Table 1 for enrollment criteria). The key inclusion criterion for RESPOnD is the performance of an ERCP in a treatment-naïve patient for the indication of suspected SOD. For descriptive purposes and in keeping with the Rome IV definition of SOD, subjects in RESPOnD are dichotomized by those with and without the diagnosis of idiopathic recurrent acute pancreatitis (iRAP; or pancreatic SOD). 3 iRAP is defined by physician report and does not require 2 separate episodes meeting the revised Atlanta criteria or other expert criteria for recurrent acute pancreatitis. 4 See the Supplementary Methods for additional methodology.ResultsBetween January 2018 and June 2020, the first 140 subjects enrolled in RESPOnD were compared with the randomized cohort from EPISOD (n= 214). Using Rome III definitions, 5 RESPOnD subtypes include biliary type I (n= 21), type II (n= 44), type III (n= 17), pancreatic (n= 48), and unknown (n= 10). Compared with EPISOD, subjects enrolled in RESPOnD are significantly older (Supplementary Table 2), and the majority (56%) of patients with biliary SOD had more than a 2-fold increase in at least 1 liver chemistry, with duct dilation less common (Table 1).
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影响因子：
4.3
作者：
Durkalski, Valerie;Stewart, Walter;Cotton, Peter
通讯作者：
Cotton, Peter
内窥镜括约肌切开术对可疑的ODDI功能障碍括约肌对胆囊切除术后疼痛相关的残疾的括约肌的影响：EPIPOD随机临床试验。
影响因子：
120.7
作者：
Cotton, Peter B.;Durkalski, Valerie;Romagnuolo, Joseph;Pauls, Qi;Fogel, Evan;Tarnasky, Paul;Aliperti, Giuseppe;Freeman, Martin;Kozarek, Richard;Jamidar, Priya;Wilcox, Mel;Serrano, Jose;Brawman-Mintzer, Olga;Elta, Grace;Mauldin, Patrick;Thornhill, Andre;Hawes, Robert;Wood-Williams, April;Orrell, Kyle;Drossman, Douglas;Robuck, Patricia
通讯作者：
Robuck, Patricia
影响因子：
29.4
作者：
Behar, Jose;Corazziari, Enrico;Toouli, James
通讯作者：
Toouli, James
影响因子：
29.4
作者：
Cotton, Peter B.;Elta, Grace H.;Corazziari, Enrico S.
通讯作者：
Corazziari, Enrico S.
影响因子：
24.5
作者：
Banks, Peter A.;Bollen, Thomas L.;Vege, Santhi Swaroop
通讯作者：
Vege, Santhi Swaroop