Aspirin-exacerbated respiratory disease in China: A cohort investigation and literature review
Aspirin-exacerbated respiratory disease in China: A cohort investigation and literature review
复制标题
阿司匹林加剧中国呼吸系统疾病：队列研究和文献综述
DOI：
10.2500/ajra.2012.26.3738
复制
发表时间：
2012-01-01
影响因子：
2.6
通讯作者：
Li, Huabin
中科院分区：
文献类型：
--
作者：
Fan, Yunping;Feng, Shaoyan;Li, Huabin
背景：尽管阿斯匹林加重呼吸系统疾病（AERD）在西方人群中发病率很高，但在中国却相当罕见，迄今为止也很少有相关研究发表。方法我们对中国南方慢性鼻窦炎（CRS）患者的AERD发病率进行了前瞻性队列调查。通过对中国学术期刊网络出版数据库的文献检索，对中国人群中AERD的发病率进行了综述，并对以往关于AERD发病率的研究进行了综述。结果在351例连续CRS患者中发现2例阿司匹林超敏反应（其中309例伴有鼻息肉[NPs]），发生率为0.57%。通过中文文献检索获得有关AERD的文献45篇。在过去30年中，共报告了346例AERD病例。结论在中国NPs人群较多的情况下，AERD的患病率很低，这可能与鼻组织嗜酸性粒细胞水平降低以及随之而来的哮喘合病率低有关。
Background Although the prevalence of aspirin-exacerbated respiratory disease (AERD) in western populations is high, AERD is rather rare in China, and few related studies have been published to date. Methods We performed a prospective cohort investigation on the incidence of AERD in patients with chronic rhinosinusitis (CRS) in southern China. A literature search of the China Academic Journal Network Publishing Database was conducted to obtain an overview of the incidence of AERD in the Chinese population, and previous studies on the incidence of AERD were reviewed. Results We found 2 patients with aspirin hypersensitivity among 351 consecutive CRS (309 with nasal polyps [NPs]) patients, suggesting a rate of 0.57% in the CRS population. Forty-five articles about AERD were obtained by Chinese-language literature searches. In total, 346 cases of AERD were reported during the past 30 years. Conclusion Given the large population of NPs in China, the prevalence of AERD is very low, and this may be related to the reduced levels of nasal tissue eosinophilia and subsequent low asthma comorbidity.