Climate change is associated with male: female ratios of fetal deaths and newborn infants in Japan
Climate change is associated with male: female ratios of fetal deaths and newborn infants in Japan
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DOI：
10.1016/j.fertnstert.2014.07.1213
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发表时间：
2014-11-01
影响因子：
6.7
通讯作者：
Andersen, Claus Yding
中科院分区：
文献类型：
--
作者：
Fukuda, Misao;Fukuda, Kiyomi;Andersen, Claus Yding
目的：评估气候变化是否与日本胎儿死亡和出生的男女比例（性别比）有关。设计：一项基于人群的队列研究。设定：不适用。患者：新生儿和妊娠12周后自然流产的胎儿。干预措施：无。主要观察指标：每年胎儿死亡和新生儿的性别比，每月胎儿死亡率和新生儿的性别比。结果：发现每年的温度差异与胎儿死亡的性别比之间存在统计学显著的正相关。从1968年到2012年，气温差异与新生儿性别比之间以及出生性别比与胎儿死亡性别比之间存在统计学显著负相关。胎儿死亡的性别比随着温度的差异沿着稳步上升，而新生儿的性别比自1970年代以来一直在下降。2010年的一个非常炎热的夏天和2011年1月的一个非常寒冷的冬天这两个极端气候不仅显示了2011年6月和2011年10月9个月后新生儿性别比的统计学显着下降，而且还显示了2010年9月和2011年1月的胎儿死亡率的统计学显着增加。日本最近的气温波动似乎与新生儿的男女性别比例较低有关，部分原因是男性胎儿死亡增加。男性生殖器似乎特别容易受到外部压力因素的影响，包括气候变化。(C)2014年，美国生殖医学会（American Society for Reproductive Medicine）
Objective: To evaluate whether climate change is associated with male: female ratios (sex ratios) of fetal deaths and births in Japan.Design: A population-based cohort study. Setting: Not applicable.Patient(s): Newborn infants and fetuses spontaneously aborted after 12 weeks of gestation.Intervention(s): None.Main Outcome Measure(s): Yearly sex ratios of fetal deaths and newborn infants and monthly fetal death rates and sex ratios of newborn infants.Result(s): A statistically significant positive association was found between yearly temperature differences and sex ratios of fetal deaths; a statistically significant negative association was found between temperature differences and sex ratios of newborn infants from 1968 to 2012, and between sex ratios of births and of fetal deaths. The sex ratios of fetal deaths have been increasing steadily along with temperature differences, whereas the sex ratios of newborn infants have been decreasing since the 1970s. Two climate extremes, a very hot summer in 2010 and a very cold winter in January 2011, showed not only statistically significant declines in sex ratios of newborn infants 9 months later in June 2011 and October 2011 but also statistically significant increases of fetal death rates immediately, in September 2010 and January 2011.Conclusion(s): The recent temperature fluctuations in Japan seem to be linked to a lower male: female sex ratio of newborn infants, partly via increased male fetal deaths. Male concepti seem to be especially vulnerable to external stress factors, including climate changes. (C) 2014 by American Society for Reproductive Medicine.