How do the Fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?
How do the Fat-Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?
复制标题
脂肪Dachsous和核心平面极性通路如何共同和独立地协调极化细胞行为？
DOI：
10.1098/rsob.200356
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发表时间：
2021-03
期刊：
影响因子：
5.8
通讯作者：
Strutt D
中科院分区：
文献类型：
--
作者：
Strutt H;Strutt D
平面极性描述了组织平面内细胞的协调极化。这是由果蝇中的两个主要途径控制：卷曲依赖的核心平面极性途径和脂肪Dachsous途径。这两种途径的成分在细胞内响应于长距离上游信号而变得不对称地定位，并形成连接相邻细胞之间极性的细胞间复合物。这篇综述探讨了这两种途径是否以及何时耦合，重点是果蝇的翅膀，眼睛和腹部。有强有力的证据表明，这些途径在表达核心蛋白Prickle特定亚型（即Spiny-legs）的组织中是分子偶联的。然而，在其他情况下，途径之间的联系是间接的。我们讨论了这两种途径如何共同作用和独立介导细胞结构和行为极化的各种影响。
Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway. Components of both of these pathways become asymmetrically localized within cells in response to long-range upstream cues, and form intercellular complexes that link polarity between neighbouring cells. This review examines if and when the two pathways are coupled, focusing on the Drosophila wing, eye and abdomen. There is strong evidence that the pathways are molecularly coupled in tissues that express a specific isoform of the core protein Prickle, namely Spiny-legs. However, in other contexts, the linkages between the pathways are indirect. We discuss how the two pathways act together and independently to mediate a diverse range of effects on polarization of cell structures and behaviours.