Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 using ionic liquids as a dual solvent-catalyst at atmospheric pressure
Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 using ionic liquids as a dual solvent-catalyst at atmospheric pressure
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在大气压下使用离子液体作为双溶剂催化剂从 CO2 高效合成喹唑啉-2,4(1H,3H)-二酮
DOI：
10.1039/c3gc41467a
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发表时间：
2014-01-01
期刊：
影响因子：
9.8
通讯作者：
Han, Buxing
中科院分区：
文献类型：
--
作者：
Lu, Wenjing;Ma, Jun;Han, Buxing
将二氧化碳高效转化为增值化学品是绿色化学中一个有趣的话题。在这项工作中，我们研究了在一系列离子液体 (IL) 中从 CO2 和 2-氨基苯甲腈合成喹唑啉-2,4(1H,3H)-二酮。结果发现，1-丁基-3-甲基咪唑鎓乙酸酯（[Bmim]Ac）是一种简单易制备的离子液体，既可以作为溶剂又可以作为催化剂，反应可以在CO2常压下非常有效地进行，并且获得高产率的产物。进一步的研究表明，IL 在大气压下也能非常有效地将其他 2-氨基苯甲腈转化为相应的喹唑啉-2,4(1H,3H)-二酮，产率高。此外，产物与离子液体的分离非常容易，并且离子液体可以重复使用至少五次，而不会显着损失催化活性。
The highly efficient transformation of CO2 into value-added chemicals is an interesting topic in green chemistry. In this work, we studied the synthesis of quinazoline-2,4(1H,3H)-diones from CO2 and 2-aminobenzonitriles in a series of ionic liquids (ILs). It was found that 1-butyl-3-methylimidazolium acetate ([Bmim]Ac), a simple and easily prepared IL, could act as both solvent and catalyst, the reactions could be carried out very efficiently at atmospheric pressure of CO2, and a high yield of the products was obtained. Further study indicated that the IL was also very efficient for converting other 2-aminobenzonitriles into their corresponding quinazoline-2,4(1H,3H)-diones in high yields at atmospheric pressure. Moreover, the separation of the products from the IL was very easy, and the IL could be reused at least five times without considerable loss in catalytic activity.